Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry.

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作者： Taha,Azad ^[1] ; Ragunath,Singaravelu ^[1] ; Zaid,Taha ^[1] ; Taylor R,Jamieson ^[1] ; Stephen,Boulton ^[1] ; Mathieu J F,Crupi ^[1] ; Nikolas T,Martin ^[1] ; Emily E F,Fekete ^[1] ; Joanna,Poutou ^[1] ; Mina,Ghahremani ^[2] ; Adrian,Pelin ^[1] ; Kazem,Nouri ^[3] ; Reza,Rezaei ^[1] ; Christopher Boyd,Marshall ^[3] ; Masahiro,Enomoto ^[3] ; Rozanne,Arulanandam ^[4] ; Nouf,Alluqmani ^[1] ; Reuben,Samson ^[5] ; Anne-Claude,Gingras ^[5] ; D William,Cameron ^[1] ; Peter A,Greer ^[6] ; Carolina S,Ilkow ^[1] ; Jean-Simon,Diallo ^[1] ; John C,Bell ^[7]

作者单位： Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[1] Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada. ^[2] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. ^[3] Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[4] Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[5] Department of Pathology and Molecular Medicine, Queens University, Kingston, ON K7L 3N6, Canada. ^[6] Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: jbell@ohri.ca. ^[7]

关键词 2019-nCoV COVID-19 SARS-CoV-2 bioluminescence bioreporter coronavirus high-throughput screening viral entry