P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9.

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作者： Xiaobing,Tian ^[1] ; Nagib,Ahsan ^[2] ; Amriti,Lulla ^[3] ; Avital,Lev ^[3] ; Philip,Abbosh ^[3] ; David T,Dicker ^[1] ; Shengliang,Zhang ^[1] ; Wafik S,El-Deiry ^[4]

作者单位： Laboratory of Translational Oncology and Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, RI, USA; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA; Department of Pathology and Laboratory Medicine, Brown University Alpert Medical School, Providence, RI, USA; Division of Biology and Medicine, Brown University, Providence, RI, USA; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA. ^[1] The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA; COBRE Center for Cancer Research Development, Proteomics Core Facility, Rhode Island Hospital, Providence, RI, USA; Division of Biology and Medicine, Brown University, Providence, RI, USA. ^[2] Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA. ^[3] Laboratory of Translational Oncology and Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, RI, USA; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI, USA; Department of Pathology and Laboratory Medicine, Brown University Alpert Medical School, Providence, RI, USA; Division of Biology and Medicine, Brown University, Providence, RI, USA; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA; Hematology-Oncology Division, Department of Medicine, Rhode Island Hospital and Brown University, Providence, RI, USA. Electronic address: wafik@brown.edu. ^[4]

关键词 ATF4 CDK9 Cancer therapy DR5 ERK1/2 MYC Mutant p53 PG3-Oc PUMA p53 pathway restoration