IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.

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作者： Eleonora,Adami ^[1] ; Sivakumar,Viswanathan ^[1] ; Anissa A,Widjaja ^[1] ; Benjamin,Ng ^[2] ; Sonia,Chothani ^[1] ; Nevin,Zhihao ^[2] ; Jessie,Tan ^[2] ; Pei Min,Lio ^[2] ; Benjamin L,George ^[1] ; Umut,Altunoglu ^[3] ; Kakaly,Ghosh ^[4] ; Bhairav S,Paleja ^[5] ; Sebastian,Schafer ^[1] ; Bruno,Reversade ^[2] ; Salvatore,Albani ^[3] ; Andrea Low Hsiu,Ling ^[4] ; Steven,O'Reilly ^[5] ; Stuart A,Cook ^[6]

作者单位： Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School. ^[1] National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore. ^[2] Department of Medical Genetics, Koç University, School of Medicine, Istanbul, Turkey. ^[3] Genome Institute of Singapore, Human Genetics and Therapeutics Laboratory. ^[4] Institute of Molecular and Cellular Biology, A*STAR. ^[5] Department of Paediatrics, National University of Singapore. ^[6] Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre. ^[7] Department of Rheumatology and Immunology, Singapore General Hospital. ^[8] Duke-National University of Singapore Medical School, Singapore. ^[9] Department of Biosciences, Durham University, Durham. ^[10] MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. ^[11]

关键词 IL11 IL11RA TGFβ2 antibody therapy fibrosis neutralizing antibody systemic sclerosis