Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells.
第一作者:
Rebekka,Duhen
第一单位:
Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. rebekka.duhen@providence.org.
作者:
主题词
活组织检查(Biopsy);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞增殖(Cell Proliferation);克隆细胞(Clone Cells);无病生存(Disease-Free Survival);表位(Epitopes);人乳头瘤病毒16(Human papillomavirus 16);人类(Humans);Kaplan-Meiers评估(Kaplan-Meier Estimate);淋巴细胞活化(Lymphocyte Activation);淋巴细胞亚群(Lymphocyte Subsets);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);肿瘤辅助疗法(Neoadjuvant Therapy);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);受体, OX40(Receptors, OX40);间质细胞(Stromal Cells)
DOI
10.1038/s41467-021-21383-1
PMID
33594075
发布时间
2021-03-05
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