换一批A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
第一作者：
Juliette,Coignard
第一单位：
Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France.;Institut Curie Paris, Paris, France.;Mines ParisTech Fontainebleau, Paris, France.;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;PSL University Paris, Paris, France.;Paris Sud University, Orsay, France.
作者：
Juliette,Coignard [1]
;
Michael,Lush [2]
;
Jonathan,Beesley [3]
;
Tracy A,O'Mara [3]
;
Joe,Dennis [2]
;
Jonathan P,Tyrer [4]
;
Daniel R,Barnes [2]
;
Lesley,McGuffog [2]
;
Goska,Leslie [2]
;
Manjeet K,Bolla [2]
;
Muriel A,Adank [5]
;
Simona,Agata [6]
;
Thomas,Ahearn [7]
;
Kristiina,Aittomäki [8]
;
Irene L,Andrulis [9]
;
Hoda,Anton-Culver [10]
;
Volker,Arndt [11]
;
Norbert,Arnold [12]
;
Kristan J,Aronson [13]
;
Banu K,Arun [14]
;
Annelie,Augustinsson [15]
;
Jacopo,Azzollini [16]
;
Daniel,Barrowdale [2]
;
Caroline,Baynes [4]
;
Heiko,Becher [17]
;
Marina,Bermisheva [18]
;
Leslie,Bernstein [19]
;
Katarzyna,Białkowska [20]
;
Carl,Blomqvist [21]
;
Stig E,Bojesen [22]
;
Bernardo,Bonanni [23]
;
Ake,Borg [24]
;
Hiltrud,Brauch [25]
;
Hermann,Brenner [26]
;
Barbara,Burwinkel [27]
;
Saundra S,Buys [28]
;
Trinidad,Caldés [29]
;
Maria A,Caligo [30]
;
Daniele,Campa [31]
;
Brian D,Carter [32]
;
Jose E,Castelao [33]
;
Jenny,Chang-Claude [34]
;
Stephen J,Chanock [7]
;
Wendy K,Chung [35]
;
Kathleen B M,Claes [36]
;
Christine L,Clarke [37]
;
GEMO Study Collaborators [38]
;
EMBRACE Collaborators [4]
;
J Margriet,Collée [39]
;
Don M,Conroy [40]
;
Kamila,Czene [41]
;
Mary B,Daly [42]
;
Peter,Devilee [19]
;
Orland,Diez [43]
;
Yuan Chun,Ding [44]
;
Susan M,Domchek [45]
;
Thilo,Dörk [4]
;
Isabel,Dos-Santos-Silva [46]
;
Alison M,Dunning [47]
;
Miriam,Dwek [48]
;
Diana M,Eccles [49]
;
A Heather,Eliassen [39]
;
Christoph,Engel [50]
;
Mikael,Eriksson [51]
;
D Gareth,Evans [52]
;
Peter A,Fasching [53]
;
Henrik,Flyger [54]
;
Florentia,Fostira [55]
;
Eitan,Friedman [2]
;
Lin,Fritschi [56]
;
Debra,Frost [32]
;
Manuela,Gago-Dominguez [57]
;
Susan M,Gapstur [58]
;
Judy,Garber [7]
;
Vanesa,Garcia-Barberan [58]
;
Montserrat,García-Closas [32]
;
José A,García-Sáenz [59]
;
Mia M,Gaudet [60]
;
Simon A,Gayther [61]
;
Andrea,Gehrig [62]
;
Vassilios,Georgoulias [63]
;
Graham G,Giles [64]
;
Andrew K,Godwin [65]
;
Mark S,Goldberg [66]
;
David E,Goldgar [67]
;
Anna,González-Neira [68]
;
Mark H,Greene [69]
;
Pascal,Guénel [70]
;
Lothar,Haeberle [71]
;
Eric,Hahnen [72]
;
Christopher A,Haiman [73]
;
Niclas,Håkansson [74]
;
Per,Hall [4]
;
Ute,Hamann [75]
;
Patricia A,Harrington [39]
;
Steven N,Hart [5]
;
Wei,He [76]
;
Frans B L,Hogervorst [77]
;
Antoinette,Hollestelle [78]
;
John L,Hopper [79]
;
Darling J,Horcasitas [80]
;
Peter J,Hulick [81]
;
David J,Hunter [76]
;
Evgeny N,Imyanitov [82]
;
KConFab Investigators [83]
;
HEBON Investigators [84]
;
ABCTB Investigators [85]
;
Agnes,Jager [86]
;
Anna,Jakubowska [87]
;
Paul A,James [88]
;
Uffe Birk,Jensen [89]
;
Esther M,John [90]
;
Michael E,Jones [91]
;
Rudolf,Kaaks [92]
;
Pooja Middha,Kapoor [93]
;
Beth Y,Karlan [94]
;
Renske,Keeman [95]
;
Elza,Khusnutdinova [85]
;
Johanna I,Kiiski [96]
;
Yon-Dschun,Ko [97]
;
Veli-Matti,Kosma [98]
;
Peter,Kraft [89]
;
Allison W,Kurian [99]
;
Yael,Laitman [75]
;
Diether,Lambrechts [100]
;
Loic,Le Marchand [67]
;
Jenny,Lester [4]
;
Fabienne,Lesueur [94]
;
Tricia,Lindstrom [16]
;
Adria,Lopez-Fernández [101]
;
Jennifer T,Loud [76]
;
Craig,Luccarini [99]
;
Arto,Mannermaa [102]
;
Siranoush,Manoukian [103]
;
Sara,Margolin [62]
;
John W M,Martens [6]
;
Noura,Mebirouk [43]
;
Alfons,Meindl [19]
;
Austin,Miller [92]
;
Roger L,Milne [104]
;
Marco,Montagna [105]
;
Katherine L,Nathanson [106]
;
Susan L,Neuhausen [75]
;
Heli,Nevanlinna [15]
;
Finn C,Nielsen [107]
;
Katie M,O'Brien [108]
;
Olufunmilayo I,Olopade [44]
;
Janet E,Olson [3]
;
Håkan,Olsson [109]
;
Ana,Osorio [110]
;
Laura,Ottini [111]
;
Tjoung-Won,Park-Simon [45]
;
Michael T,Parsons [112]
;
Inge Sokilde,Pedersen [113]
;
Beth,Peshkin [75]
;
Paolo,Peterlongo [36]
;
Julian,Peto [46]
;
Paul D P,Pharoah [114]
;
Kelly-Anne,Phillips [115]
;
Eric C,Polley [116]
;
Bruce,Poppe [117]
;
Nadege,Presneau [118]
;
Miquel Angel,Pujana [119]
;
Kevin,Punie [119]
;
Paolo,Radice [120]
;
Johanna,Rantala [121]
;
Muhammad U,Rashid [104]
;
Gad,Rennert [122]
;
Hedy S,Rennert [105]
;
Mark,Robson [123]
;
Atocha,Romero [124]
;
Maria,Rossing [125]
;
Emmanouil,Saloustros [126]
;
Dale P,Sandler [75]
;
Regina,Santella [127]
;
Maren T,Scheuner [128]
;
Marjanka K,Schmidt [129]
;
Gunnar,Schmidt [130]
;
Christopher,Scott [131]
;
Priyanka,Sharma [132]
;
Penny,Soucy [133]
;
Melissa C,Southey [134]
;
John J,Spinelli [135]
;
Zoe,Steinsnyder [47]
;
Jennifer,Stone [136]
;
Dominique,Stoppa-Lyonnet [123]
;
Anthony,Swerdlow [137]
;
Rulla M,Tamimi [138]
;
William J,Tapper [139]
;
Jack A,Taylor [140]
;
Mary Beth,Terry [141]
;
Alex,Teulé [142]
;
Darcy L,Thull [68]
;
Marc,Tischkowitz [143]
;
Amanda E,Toland [144]
;
Diana,Torres [145]
;
Alison H,Trainer [146]
;
Thérèse,Truong [2]
;
Nadine,Tung [70]
;
Celine M,Vachon [147]
;
Ana,Vega [148]
;
Joseph,Vijai [149]
;
Qin,Wang [150]
;
Barbara,Wappenschmidt [151]
;
Clarice R,Weinberg [7]
;
Jeffrey N,Weitzel [53]
;
Camilla,Wendt [152]
;
Alicja,Wolk [10]
;
Siddhartha,Yadav [153]
;
Xiaohong R,Yang [154]
;
Drakoulis,Yannoukakos [155]
;
Wei,Zheng [146]
;
Argyrios,Ziogas [70]
;
Kristin K,Zorn [156]
;
Sue K,Park [10]
;
Mads,Thomassen [3]
;
Kenneth,Offit [112]
;
Rita K,Schmutzler [157]
;
Fergus J,Couch [158]
;
Jacques,Simard ;
Georgia,Chenevix-Trench ;
Douglas F,Easton ;
Nadine,Andrieu ;
Antonis C,Antoniou
作者单位：
Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France.;Institut Curie Paris, Paris, France.;Mines ParisTech Fontainebleau, Paris, France.;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;PSL University Paris, Paris, France.;Paris Sud University, Orsay, France.
[1]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[2]
Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
[3]
Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge, Cambridge, UK.
[4]
Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
[5]
Immunology and Molecular Oncology, Unit Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
[6]
Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
[7]
Department of Clinical Genetics, Helsinki University Hospital University of Helsinki, Helsinki, Finland.
[8]
Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.;Department of Molecular Genetics University of Toronto, Toronto, ON, Canada.
[9]
Department of Epidemiology, Genetic Epidemiology Research Institute University of California Irvine, Irvine, CA, USA.
[10]
Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ), Heidelberg, Germany.
[11]
Department of Gynaecology and Obstetrics University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.;Institute of Clinical Molecular Biology University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
[12]
Department of Public Health Sciences, and Cancer Research Institute Queen's University, Kingston, ON, Canada.
[13]
Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[14]
Department of Cancer Epidemiology, Clinical Sciences Lund University, Lund, 22242, Sweden.
[15]
Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
[16]
Institute for Medical Biometrics and Epidemiology University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[17]
Institute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
[18]
Department of Population Sciences Beckman Research Institute of City of Hope, Duarte, CA, USA.
[19]
Department of Genetics and Pathology Pomeranian Medical University Szczecin, Szczecin, Poland.
[20]
Department of Oncology, Helsinki University Hospital University of Helsinki, Helsinki, Finland.;Department of Oncology Örebro University Hospital, Örebro, Sweden.
[21]
Copenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.;Department of Clinical Biochemistry, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.;Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark.
[22]
Division of Cancer Prevention and Genetics IEO, European Institute of Oncology IRCCS, Milan, Italy.
[23]
Department of Oncology Lund University and Skåne University Hospital, Lund, Sweden.
[24]
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.;iFIT-Cluster of Excellence University of Tübingen, Tübingen, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
[25]
Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ), Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[26]
Molecular Epidemiology Group, C080 German Cancer Research Center (DKFZ), Heidelberg, Germany.;Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg University of Heidelberg, Heidelberg, Germany.
[27]
Department of Medicine Huntsman Cancer Institute, Salt Lake City, UT, USA.
[28]
Molecular Oncology Laboratory CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
[29]
SOD Genetica Molecolare University Hospital, Pisa, Italy.
[30]
Department of Biology University of Pisa, Pisa, Italy.;Division of Cancer Epidemiology German Cancer Research Center (DKFZ), Heidelberg, Germany.
[31]
Behavioral and Epidemiology Research Group American Cancer Society Atlanta, Atlanta, GA, USA.
[32]
Oncology and Genetics Unit Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.
[33]
Division of Cancer Epidemiology German Cancer Research Center (DKFZ), Heidelberg, Germany.;Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH) University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[34]
Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
[35]
Centre for Medical Genetics Ghent University, Gent, Belgium.
[36]
Westmead Institute for Medical Research University of Sydney, Sydney, NSW, Australia.
[37]
Department of Clinical Genetics Erasmus University Medical Center, Rotterdam, The Netherlands.
[38]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[39]
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia, Philadelphia, PA, USA.
[40]
Department of Pathology Leiden University Medical Center, Leiden, The Netherlands.;Department of Human Genetics Leiden University Medical Center, Leiden, The Netherlands.
[41]
Oncogenetics Group Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.;Clinical and Molecular Genetics Area University Hospital Vall d'Hebron, Barcelona, Spain.
[42]
Basser Center for BRCA, Abramson Cancer Center University of Pennsylvania, Philadelphia, PA, USA.
[43]
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
[44]
Department of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine, London, UK.
[45]
School of Life Sciences University of Westminster, London, UK.
[46]
Faculty of Medicine University of Southampton, Southampton, UK.
[47]
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Epidemiology Harvard TH Chan School of Public Health, Boston, MA, USA.
[48]
Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany.
[49]
Genomic Medicine, Division of Evolution and Genomic Sciences The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St Mary's Hospital, Manchester, UK.;Genomic Medicine, North West Genomics hub Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St Mary's Hospital, Manchester, UK.
[50]
David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology University of California at Los Angeles, Los Angeles, CA, USA.;Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg, Erlangen, Germany.
[51]
Department of Breast Surgery, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.
[52]
Molecular Diagnostics Laboratory, INRASTES National Centre for Scientific Research íDemokritosí, Athens, Greece.
[53]
The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center, Ramat Gan, Israel.;Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Israel.
[54]
School of Public Health Curtin University, Perth, Western Australia, Australia.
[55]
Genomic Medicine Group, Galician Foundation of Genomic Medicine Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.;Moores Cancer Center University of California, San Diego La Jolla, CA, USA.
[56]
Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA, USA.
[57]
Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
[58]
Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core Cedars-Sinai Medical Center, Los Angeles, CA, USA.
[59]
Department of Human Genetics University Würzburg, Würzburg, Germany.
[60]
Department of Medical Oncology University Hospital of Heraklion, Heraklion, Greece.
[61]
Cancer Epidemiology Division Cancer Council Victoria, Melbourne, VIC, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health Monash University, Clayton, VIC, Australia.
[62]
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
[63]
Department of Medicine, McGill University, Montréal, QC, Canada.;Division of Clinical Epidemiology, Royal Victoria Hospital McGill University Montréal, Montréal, QC, Canada.
[64]
Huntsman Cancer Institute and Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
[65]
Human Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
[66]
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, Bethesda, MD, USA.
[67]
Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP) INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
[68]
Department of Gynaecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
[69]
Center for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.;Center for Integrated Oncology (CIO) Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
[70]
Department of Preventive Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, USA.
[71]
Department of Oncology, Södersjukhuset, Stockholm, Sweden.
[72]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Department of Oncology, Södersjukhuset, Stockholm, Sweden.
[73]
Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ), Heidelberg, Germany.
[74]
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
[75]
Department of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
[76]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
[77]
New Mexico Oncology Hematology Consultants, University of New Mexico, Albuquerque, NM, USA.
[78]
Center for Medical Genetics NorthShore University HealthSystem, Evanston, IL, USA.;The University of Chicago Pritzker School of Medicine Chicago, Chicago, IL, USA.
[79]
Department of Epidemiology Harvard TH Chan School of Public Health, Boston, MA, USA.;Program in Genetic Epidemiology and Statistical Genetics Harvard TH Chan School of Public Health Boston, Boston, MA, USA.;Nuffield Department of Population Health University of Oxford, Oxford, UK.
[80]
NN Petrov Institute of Oncology, St. Petersburg, Russia.
[81]
Department of Genetics and Pathology Pomeranian Medical University Szczecin, Szczecin, Poland.;Independent Laboratory of Molecular Biology and Genetic Diagnostics Pomeranian Medical University, Szczecin, Poland.
[82]
Sir Peter MacCallum Department of Oncology The University of Melbourne, Melbourne, VIC, Australia.;Parkville Familial Cancer Centre Peter MacCallum Cancer Center, Melbourne, VIC, Australia.
[83]
Department of Clinical Genetics Aarhus, University Hospital, Aarhus, Denmark.
[84]
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.;Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
[85]
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
[86]
Division of Cancer Epidemiology German Cancer Research Center (DKFZ), Heidelberg, Germany.
[87]
Division of Cancer Epidemiology German Cancer Research Center (DKFZ), Heidelberg, Germany.;Division of Genetics and Epidemiology The Institute of Cancer Research, London, UK.
[88]
Faculty of Medicine University of Heidelberg, Heidelberg, Germany.;David Geffen School of Medicine, Department of Obstetrics and Gynecology University of California at Los Angeles, Los Angeles, CA, USA.
[89]
Womenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center, Los Angeles, CA, USA.
[90]
Institute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.;Division of Molecular Pathology The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
[91]
Department of Genetics and Fundamental Medicine Bashkir State Medical University, Ufa, Russia.
[92]
Department of Obstetrics and Gynecology, Helsinki University Hospital University of Helsinki, Helsinki, Finland.
[93]
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus, Bonn, Germany.;Translational Cancer Research Area University of Eastern Finland, Kuopio, Finland.;Institute of Clinical Medicine, Pathology and Forensic Medicine University of Eastern Finland, Kuopio, Finland.
[94]
Department of Epidemiology Harvard TH Chan School of Public Health, Boston, MA, USA.;Program in Genetic Epidemiology and Statistical Genetics Harvard TH Chan School of Public Health Boston, Boston, MA, USA.
[95]
The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center, Ramat Gan, Israel.
[96]
VIB Center for Cancer Biology, Leuven, Belgium.;Laboratory for Translational Genetics, Department of Human Genetics University of Leuven, Leuven, Belgium.
[97]
Epidemiology Program University of Hawaii Cancer Center, Honolulu, HI, USA.
[98]
Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France.;Institut Curie Paris, Paris, France.;Mines ParisTech Fontainebleau, Paris, France.;PSL University Paris, Paris, France.
[99]
High Risk and Cancer Prevention Group Vall d'Hebron Institute of Oncology, Barcelona, Spain.
[100]
Department of Oncology, Södersjukhuset, Stockholm, Sweden.;Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet, Stockholm, Sweden.
[101]
Department of Gynecology and Obstetrics University of Munich, Campus Grosshadern, Munich, Germany.
[102]
NRG Oncology, Statistics and Data Management Center Roswell Park Cancer Institute, Buffalo, NY, USA.
[103]
Center for Genomic Medicine Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[104]
Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park, Durham, NC, USA.
[105]
Center for Clinical Cancer Genetics The University of Chicago, Chicago, IL, USA.
[106]
Human Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO), Madrid, Spain.;Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
[107]
Department of Molecular Medicine University La Sapienza, Rome, Italy.
[108]
Molecular Diagnostics Aalborg University Hospital, Aalborg, Denmark.;Clinical Cancer Research Center Aalborg University Hospital, Aalborg, Denmark.;Department of Clinical Medicine Aalborg University, Aalborg, Denmark.
[109]
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
[110]
Genome Diagnostics Program IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
[111]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge, Cambridge, UK.
[112]
Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.;Sir Peter MacCallum Department of Oncology The University of Melbourne, Melbourne, VIC, Australia.
[113]
Translational Research Laboratory IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
[114]
Leuven Multidisciplinary Breast Center, Department of Oncology Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
[115]
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
[116]
Clinical Genetics Karolinska Institutet, Stockholm, Sweden.
[117]
Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Basic Sciences Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan.
[118]
Clalit National Cancer Control Center Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
[119]
Clinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[120]
Medical Oncology Department Hospital Universitario Puerta de Hierro, Madrid, Spain.
[121]
Department of Oncology University Hospital of Larissa, Larissa, Greece.
[122]
Department of Epidemiology, Mailman School of Public Health Columbia University, New York, NY, USA.
[123]
Cancer Genetics and Prevention Program University of California San Francisco, San Francisco, CA, USA.
[124]
Womenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center, Los Angeles, CA, USA.;Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
[125]
Institute of Human Genetics Hannover Medical School, Hannover, Germany.
[126]
Department of Internal Medicine, Division of Medical Oncology University of Kansas Medical Center, Westwood, KS, USA.
[127]
Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.
[128]
Precision Medicine, School of Clinical Sciences at Monash Health Monash University, Clayton, VIC, Australia.;Department of Clinical Pathology The University of Melbourne, Melbourne, VIC, Australia.
[129]
Population Oncology BC Cancer, Vancouver, BC, Canada.;School of Population and Public Health University of British Columbia, Vancouver, BC, Canada.
[130]
Clinical Genetics Research Lab, Department of Cancer Biology and Genetics Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[131]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.;The Curtin UWA Centre for Genetic Origins of Health and Disease Curtin University and University of Western Australia, Perth, Western Australia, Australia.
[132]
Service de Génétique Institut Curie, Paris, France.;Department of Tumour Biology INSERM U830, Paris, France.;Université Paris Descartes, Paris, France.
[133]
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.;Division of Breast Cancer Research Institute of Cancer Research, London, UK.
[134]
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Epidemiology Harvard TH Chan School of Public Health, Boston, MA, USA.;Program in Genetic Epidemiology and Statistical Genetics Harvard TH Chan School of Public Health Boston, Boston, MA, USA.
[135]
Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park, Durham, NC, USA.;Epigenetic and Stem Cell Biology Laboratory National Institute of Environmental Health Sciences, NIH Research Triangle Park, Triangle Park, NC, USA.
[136]
Hereditary Cancer Program ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
[137]
Department of Medicine Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
[138]
Program in Cancer Genetics, Departments of Human Genetics and Oncology McGill University, Montréal, QC, Canada.;Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge, Cambridge, UK.
[139]
Department of Cancer Biology and Genetics The Ohio State University, Columbus, OH, USA.
[140]
Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ), Heidelberg, Germany.;Institute of Human Genetics Pontificia Universidad Javeriana, Bogota, Colombia.
[141]
Parkville Familial Cancer Centre Peter MacCallum Cancer Center, Melbourne, VIC, Australia.;Department of medicine University Of Melbourne, Melbourne, VIC, Australia.
[142]
Department of Medical Oncology Beth Israel Deaconess Medical Center, Boston, MA, USA.
[143]
Department of Health Science Research, Division of Epidemiology Mayo Clinic, Rochester, MN, USA.
[144]
Fundación Pública Galega Medicina Xenómica-SERGAS, Instituto de Investigación Sanitaria Santiago de Compostela (IDIS); CIBERER, Santiago de Compostela, Spain.
[145]
Clinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer Center, New York, NY, USA.;Clinical Genetics Research Lab, Department of Cancer Biology and Genetics Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
[146]
Biostatistics and Computational Biology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park, Triangle Park, NC, USA.
[147]
Clinical Cancer Genomics City of Hope, Duarte, CA, USA.
[148]
Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet, Stockholm, Sweden.
[149]
Institute of Environmental Medicine Karolinska Institutet, Stockholm, Sweden.;Department of Surgical Sciences Uppsala University, Uppsala, Sweden.
[150]
Department of Oncology Mayo Clinic, Rochester, MN, USA.
[151]
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine, Nashville, TN, USA.
[152]
Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
[153]
Department of Preventive Medicine Seoul National University College of Medicine, Seoul, Korea.;Department of Biomedical Sciences Seoul National University Graduate School, Seoul, Korea.;Cancer Research Institute Seoul National University, Seoul, Korea.
[154]
Department of Clinical Genetics Odense University Hospital, Odence C, Denmark.
[155]
Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN, USA.
[156]
Genetic Epidemiology of Cancer team, Inserm, U900, Paris, France. nadine.andrieu@curie.fr.;Institut Curie Paris, Paris, France. nadine.andrieu@curie.fr.;Mines ParisTech Fontainebleau, Paris, France. nadine.andrieu@curie.fr.;PSL University Paris, Paris, France. nadine.andrieu@curie.fr.
[157]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. aca20@medschl.cam.ac.uk.
[158]
医学主题词
成年人(Adult);等位基因(Alleles);BRCA1蛋白质(BRCA1 Protein);BRCA2蛋白质(BRCA2 Protein);乳腺肿瘤(Breast Neoplasms);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);人类(Humans);连锁不平衡(Linkage Disequilibrium);中年人(Middle Aged);突变(Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci);危险因素(Risk Factors)
DOI
10.1038/s41467-020-20496-3
PMID
33597508
发布时间
2026-03-07
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Nature communications
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