首页> European journal of nuclear medicine and molecular imaging> Spatially constrained kinetic modeling with dual reference tissues improves <sup>18</sup>F-flortaucipir PET in studies of Alzheimer disease.

Spatially constrained kinetic modeling with dual reference tissues improves <sup>18</sup>F-flortaucipir PET in studies of Alzheimer disease.

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第一作者： Yun,Zhou

第一单位： Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd, St Louis, MO, 63110, USA. yunzhou@wustl.edu.

作者： Yun,Zhou ^[1] ; Shaney,Flores ^[2] ; Syahir,Mansor ^[2] ; Russ C,Hornbeck ^[2] ; Zhude,Tu ^[2] ; Joel S,Perlmutter ^[3] ; Beau,Ances ^[4] ; John C,Morris ^[5] ; Robert J,Gropler ^[2] ; Tammie L S,Benzinger ^[6]

作者单位： Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd, St Louis, MO, 63110, USA. yunzhou@wustl.edu. ^[1] Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd, St Louis, MO, 63110, USA. ^[2] Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd, St Louis, MO, 63110, USA.;Departments of Neurology and Neuroscience, Programs of Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, MO, USA. ^[3] Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA. ^[4] Departments of Neurology and Neuroscience, Programs of Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, MO, USA.;Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA. ^[5] Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd, St Louis, MO, 63110, USA.;Departments of Neurology and Neuroscience, Programs of Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, MO, USA.;Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA. ^[6]

关键词 18F-Flortaucipir PET Alzheimer disease Dual reference tissues Logan plot SRTM SUVR Spatially constrained kinetic modeling

医学主题词阿尔茨海默病(Alzheimer Disease);脑(Brain);咔啉类(Carbolines);人类(Humans);正电子发射断层显像术(Positron-Emission Tomography);tau蛋白质类(tau Proteins)

DOI 10.1007/s00259-020-05134-w

PMID 33599811

发布时间 2024-06-10

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