Cocrystals of Apixaban with Improved Solubility and Permeability: Formulation, Physicochemical Characterization, Pharmacokinetic Evaluation, and Computational Studies.

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作者： Jyotsana R,Madan ^[1] ; Savita V,Waghmare ^[1] ; Rajesh B,Patil ^[1] ; Rajendra,Awasthi ^[2] ; Kamal,Dua ^[3]

作者单位： Department of Pharmaceutics, Smt. Kashibai Navale College of Pharmacy, Savitribai Phule Pune University, Pune, India. ^[1] Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India. ^[2] Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia. ^[3] School of Pharmacy and Biomedical Sciences, The University of Newcastle, Newcastle, Australia. ^[4]

关键词 cocrystal diffusion flux oral delivery permeability solubility

主题词动物(Animals);化学, 物理(Chemistry, Physical);鸡(Chickens);结晶学, X线(Crystallography, X-Ray);药物调剂(Drug Compounding);氢离子浓度(Hydrogen-Ion Concentration);男(雄)性(Male);分子动力学模拟(Molecular Dynamics Simulation);分子结构(Molecular Structure);通透性(Permeability);吡唑类(Pyrazoles);吡啶酮类(Pyridones);大鼠(Rats);大鼠, Wistar(Rats, Wistar);溶解度(Solubility);组织分布(Tissue Distribution)

DOI 10.1089/adt.2020.1052

PMID 33601935

发布时间 2021-10-11

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Assay and drug development technologies

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Cocrystals of Apixaban with Improved Solubility and Permeability: Formulation, Physicochemical Characterization, Pharmacokinetic Evaluation, and Computational Studies.

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Cocrystals of Apixaban with Improved Solubility and Permeability: Formulation, Physicochemical Characterization, Pharmacokinetic Evaluation, and Computational Studies.

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