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首页> Neuron> White matter aging drives microglial diversity.

White matter aging drives microglial diversity.

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第一作者： Shima,Safaiyan
第一单位： Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.
作者： Shima,Safaiyan [1] ; Simon,Besson-Girard [2] ; Tuğberk,Kaya [3] ; Ludovico,Cantuti-Castelvetri [1] ; Lu,Liu [2] ; Hao,Ji [2] ; Martina,Schifferer [4] ; Garyfallia,Gouna [1] ; Fumere,Usifo [2] ; Nirmal,Kannaiyan [5] ; Dirk,Fitzner [6] ; Xianyuan,Xiang [7] ; Moritz J,Rossner [5] ; Matthias,Brendel [8] ; Ozgun,Gokce [9] ; Mikael,Simons [10]
作者单位： Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany. [1] Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany. [2] Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany. [3] German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany. [4] Department of Psychiatry, Ludwig-Maximilians-Universität, 80336 Munich, Germany. [5] Department of Neurology, University of Göttingen, 37075 Göttingen, Germany. [6] Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität Munich, 81377 Munich, Germany. [7] Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany. [8] Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address: oezguen.goekce@med.uni-muenchen.de. [9] Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address: msimons@gwdg.de. [10]
关键词 ApoETrem2microglia, agingmyelinwhite matter
医学主题词 衰老(Aging);阿尔茨海默病(Alzheimer Disease);动物(Animals);载脂蛋白E类(Apolipoproteins E);脱髓鞘疾病(Demyelinating Diseases);基因表达调控(Gene Expression Regulation);免疫组织化学(Immunohistochemistry);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小神经胶质细胞(Microglia);髓鞘(Myelin Sheath);受体, 免疫(Receptors, Immunologic);序列分析, RNA(Sequence Analysis, RNA);信号传导(Signal Transduction);单细胞分析(Single-Cell Analysis)
DOI 10.1016/j.neuron.2021.01.027
PMID 33606969
发布时间 2021-04-27
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Neuron

Neuron

2021年109卷7期

1100-1117.e10页

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