换一批
换一批Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
作者：
Merryn,Voysey [1]
;
Sue Ann,Costa Clemens [2]
;
Shabir A,Madhi [3]
;
Lily Y,Weckx [4]
;
Pedro M,Folegatti [5]
;
Parvinder K,Aley [1]
;
Brian,Angus [5]
;
Vicky L,Baillie [3]
;
Shaun L,Barnabas [6]
;
Qasim E,Bhorat [7]
;
Sagida,Bibi [1]
;
Carmen,Briner [8]
;
Paola,Cicconi [5]
;
Elizabeth A,Clutterbuck [1]
;
Andrea M,Collins [9]
;
Clare L,Cutland [3]
;
Thomas C,Darton [10]
;
Keertan,Dheda [11]
;
Christina,Dold [1]
;
Christopher J A,Duncan [12]
;
Katherine R W,Emary [1]
;
Katie J,Ewer [5]
;
Amy,Flaxman [5]
;
Lee,Fairlie [13]
;
Saul N,Faust [14]
;
Shuo,Feng [1]
;
Daniela M,Ferreira [9]
;
Adam,Finn [15]
;
Eva,Galiza [16]
;
Anna L,Goodman [17]
;
Catherine M,Green [18]
;
Christopher A,Green [19]
;
Melanie,Greenland [1]
;
Catherine,Hill [3]
;
Helen C,Hill [9]
;
Ian,Hirsch [20]
;
Alane,Izu [3]
;
Daniel,Jenkin [5]
;
Carina C D,Joe [5]
;
Simon,Kerridge [1]
;
Anthonet,Koen [3]
;
Gaurav,Kwatra [3]
;
Rajeka,Lazarus [21]
;
Vincenzo,Libri [22]
;
Patrick J,Lillie [23]
;
Natalie G,Marchevsky [1]
;
Richard P,Marshall [20]
;
Ana V A,Mendes [24]
;
Eveline P,Milan [25]
;
Angela M,Minassian [5]
;
Alastair,McGregor [26]
;
Yama F,Mujadidi [1]
;
Anusha,Nana [8]
;
Sherman D,Padayachee [27]
;
Daniel J,Phillips [1]
;
Ana,Pittella [28]
;
Emma,Plested [1]
;
Katrina M,Pollock [29]
;
Maheshi N,Ramasamy [1]
;
Adam J,Ritchie [5]
;
Hannah,Robinson [1]
;
Alexandre V,Schwarzbold [30]
;
Andrew,Smith [31]
;
Rinn,Song [1]
;
Matthew D,Snape [1]
;
Eduardo,Sprinz [32]
;
Rebecca K,Sutherland [33]
;
Emma C,Thomson [34]
;
M Estée,Török [35]
;
Mark,Toshner [36]
;
David P J,Turner [37]
;
Johan,Vekemans [20]
;
Tonya L,Villafana [20]
;
Thomas,White [20]
;
Christopher J,Williams [38]
;
Alexander D,Douglas [5]
;
Adrian V S,Hill [5]
;
Teresa,Lambe [5]
;
Sarah C,Gilbert [5]
;
Andrew J,Pollard [39]
;
Oxford COVID Vaccine Trial Group
作者单位：
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
[1]
Institute of Global Health, University of Siena, Siena, Italy; Department of Paediatrics, University of Oxford, Oxford, UK.
[2]
South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa.
[3]
Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
[4]
Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
[5]
Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch, Cape Town, South Africa.
[6]
Soweto Clinical Trials Centre, Soweto, South Africa.
[7]
Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
[8]
Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
[9]
Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
[10]
Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa; Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.
[11]
Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK.
[12]
Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
[13]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
[14]
School of Population Health Sciences, University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, UK.
[15]
St George's Vaccine Institute, St George's, University of London, London, UK.
[16]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
[17]
Clinical BioManufacturing Facility, University of Oxford, Oxford, UK.
[18]
NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[19]
AstraZeneca BioPharmaceuticals, Cambridge, UK.
[20]
Severn Pathology, North Bristol NHS Trust, Bristol, UK.
[21]
NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, London, UK.
[22]
Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, UK.
[23]
Escola Bahiana de Medicina e Saúde Pública, Salvador, Braziland Hospital São Rafael, Salvador, Brazil; Instituto D'Or, Salvador, Brazil.
[24]
Universidade Federal do Rio Grande do Norte, Natal, Brazil.
[25]
London Northwest University Healthcare, Harrow, UK.
[26]
Setshaba Research Centre, Pretoria, South Africa.
[27]
Hospital Quinta D'Or, Rede D'Or, Rio De Janeiro, Brazil.
[28]
NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.
[29]
Clinical Research Unit, Department of Clinical Medicine, Universidade Federal de Santa Maria, Santa Maria, Brazil.
[30]
College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, UK.
[31]
Infectious Diseases Service, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
[32]
Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK.
[33]
MRC-University of Glasgow Centre for Virus Research & Department of Infectious Diseases, Queen Elizabeth University Hospital, Glasgow, UK.
[34]
Department of Medicine, University of Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[35]
Heart Lung Research Institute, Dept of Medicine, University of Cambridge and NIHR Cambridge Clinical Research Facility, Cambridge University Hospital and Royal Papworth NHS Foundation Trusts, Cambridge, UK.
[36]
University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.
[37]
Public Health Wales, Cardiff, Wales; Aneurin Bevan University Health Board, Newport, Wales.
[38]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: andrew.pollard@paediatrics.ox.ac.uk.
[39]
主题词
青少年(Adolescent);成年人(Adult);老年人(Aged);抗体生成(Antibody Formation);无症状感染(Asymptomatic Infections);人类(Humans);免疫接种程序表(Immunization Schedule);免疫接种, 加强(Immunization, Secondary);中年人(Middle Aged);随机对照试验(主题)(Randomized Controlled Trials as Topic);青年人(Young Adult)
DOI
10.1016/S0140-6736(21)00432-3
PMID
33617777
发布时间
2024-12-19
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Lancet (London, England)
Lancet (London, England)
881-891页
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