In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats.

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第一作者： Michael T,Kim

第一单位： Department of Protein Analytical Chemistry, Genentech, South San Francisco, California, USA; Department of Chemistry, University of Kansas, Lawrence, Kansas, USA. Electronic address: michaetk@gene.com.

作者： Michael T,Kim ^[1] ; Martin,Lechmann ^[2] ; Sharmila,Rajan ^[3] ; Vittal,Shivva ^[3] ; Aron,Lee ^[4] ; Yan,Chen ^[4] ; David D,Weis ^[5]

作者单位： Department of Protein Analytical Chemistry, Genentech, South San Francisco, California, USA; Department of Chemistry, University of Kansas, Lawrence, Kansas, USA. Electronic address: michaetk@gene.com. ^[1] Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Munich, Penzberg, Germany. ^[2] Department of Preclinical and Translation Pharmacokinetics, Genentech, South San Francisco, California, USA. ^[3] Department of Protein Analytical Chemistry, Genentech, South San Francisco, California, USA. ^[4] Department of Chemistry, University of Kansas, Lawrence, Kansas, USA. ^[5]

关键词 Analytical biochemistry Antibody(s)Biotechnology IgG antibody(s)Kinetics Liquid chromatography-mass spectrometry (LC-MS)Monoclonal antibody(s)Oxidation(s)Physicochemical properties Reduction(s)

主题词动物(Animals);免疫球蛋白G(Immunoglobulin G);动力学(Kinetics);质谱分析法(Mass Spectrometry);大鼠(Rats);大鼠, Wistar(Rats, Wistar);巯基化合物(Sulfhydryl Compounds)

DOI 10.1016/j.xphs.2021.02.009

PMID 33617870

发布时间 2021-06-17

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准确一般字义偏差语意偏离译文作用小提交