A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases.

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作者： Alexander G,Tkachenko ^[1] ; Natalya M,Kashevarova ^[2] ; Roman Yu,Sidorov ^[3] ; Larisa Yu,Nesterova ^[3] ; Anna V,Akhova ^[3] ; Ivan V,Tsyganov ^[3] ; Vladimir Yu,Vaganov ^[4] ; Sergei A,Shipilovskikh ^[4] ; Aleksandr E,Rubtsov ^[5] ; Andrei V,Malkov ^[6]

作者单位： Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. Electronic address: agtkachenko@iegm.ru. ^[1] Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia. ^[2] Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. ^[3] Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. ^[4] Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. Electronic address: rubtsov@psu.ru. ^[5] Department of Chemistry, Loughborough University Address: University Road, Loughborough, Leicestershire LE11 3TU, UK. Electronic address: a.malkov@lboro.ac.uk. ^[6]

关键词 (p)ppGpp synthetases Rel(Msm)RelZ biofilm formation diterpene mycobacteria persistence synthetic analogue target

主题词抗菌药(Anti-Bacterial Agents);细菌蛋白质类(Bacterial Proteins);结合部位(Binding Sites);生物膜(Biofilms);二萜类(Diterpenes);连接酶类(Ligases);微生物敏感性试验(Microbial Sensitivity Tests);耻垢分枝杆菌(Mycobacterium smegmatis);蛋白质结构, 三级(Protein Structure, Tertiary)

DOI 10.1016/j.chembiol.2021.01.018

PMID 33621482

发布时间 2022-01-03

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Cell chemical biology

2021年28卷10期

1420-1432.e9页

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A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases.

Cell chemical biology

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A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases.

Cell chemical biology

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Cell chemical biology

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