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Distinct properties and functions of CTCF revealed by a rapidly inducible degron system.

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第一作者： Jing,Luan

第一单位： Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Jing,Luan ^[1] ; Guanjue,Xiang ^[2] ; Pablo Aurelio,Gómez-García ^[3] ; Jacob M,Tome ^[4] ; Zhe,Zhang ^[5] ; Marit W,Vermunt ^[6] ; Haoyue,Zhang ^[6] ; Anran,Huang ^[6] ; Cheryl A,Keller ^[2] ; Belinda M,Giardine ^[2] ; Yu,Zhang ^[7] ; Yemin,Lan ^[8] ; John T,Lis ^[4] ; Melike,Lakadamyali ^[9] ; Ross C,Hardison ^[2] ; Gerd A,Blobel ^[10]

作者单位： Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA. ^[2] Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. ^[3] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. ^[4] Department of Biomedical and Health Informatics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA. ^[5] Division of Hematology, The Children's Hospital of Pennsylvania, Philadelphia, PA, USA. ^[6] Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA. ^[7] Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[8] Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[9] Division of Hematology, The Children's Hospital of Pennsylvania, Philadelphia, PA, USA. Electronic address: blobel@chop.edu. ^[10]

关键词 CTCF PRO-seq chromatin architecture cohesin degradation dynamics residence time single-molecule tracking transcription elongation stalling

医学主题词动物(Animals);结合部位(Binding Sites);细胞系(Cell Line);染色质(Chromatin);染色质组装和分解(Chromatin Assembly and Disassembly);幼红细胞(Erythroblasts);动力学(Kinetics);小鼠(Mice);分子动力学模拟(Molecular Dynamics Simulation);蛋白质结合(Protein Binding);RNA聚合酶Ⅱ(RNA Polymerase II);转录, 遗传(Transcription, Genetic)

DOI 10.1016/j.celrep.2021.108783

PMID 33626344

发布时间 2023-11-11

基金项目

R01 DK054937/DK/NIDDK NIH HHS/United States R01 DK058044/DK/NIDDK NIH HHS/United States R01 GM121613/GM/NIGMS NIH HHS/United States R24 DK106766/DK/NIDDK NIH HHS/United States

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