Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs.

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第一作者： Yan,Li

第一单位： National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

作者： Yan,Li ^[1] ; Xin,Chen ^[2] ; Ronghua,Jin ^[3] ; Lu,Chen ^[3] ; Ming,Dang ^[1] ; Hao,Cao ^[4] ; Yun,Dong ^[5] ; Bolei,Cai ^[5] ; Guo,Bai ^[2] ; J Justin,Gooding ^[1] ; Shiyu,Liu ^[6] ; Duohong,Zou ^[7] ; Zhiyuan,Zhang ^[8] ; Chi,Yang ^[8]

作者单位： National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. ^[1] State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. ^[2] School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Xi'an Jiao Tong University, Xi'an 710049, China. ^[3] School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA. ^[4] Department of Cardiac Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. ^[5] School of Chemistry, Australian Centre for NanoMedicine and ARC Australian, Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney 2052, Australia. ^[6] Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China. ^[7] National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. yangchi63@hotmail.com zhzhy0502@163.com zdhyy@ahmu.edu.cn. ^[8]

主题词动物(Animals);内皮细胞(Endothelial Cells);水凝胶类(Hydrogels);微RNAs(MicroRNAs);心肌梗死(Myocardial Infarction);纳米粒子(Nanoparticles);新生血管化, 病理性(Neovascularization, Pathologic);二氧化硅(Silicon Dioxide);猪(Swine)

DOI 10.1126/sciadv.abd6740

PMID 33627421

发布时间 2022-04-18

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Science advances

2021年7卷9期

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Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs.

Science advances

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Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs.

Science advances

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Science advances

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