换一批Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma.
第一作者：
Xiaohua,Liu
第一单位：
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.;School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.;University of Chinese Academy of Sciences, Beijing 100049, China.
作者：
关键词
BCC, basal cell carcinomaBET, bromo and extra C-terminal bromodomain proteinsBRD4BRD4, bromodomain-containing protein 4Drug resistanceGLIHH, hedgehogHTRF, homogeneous time-resolved fluorescenceHedgehog signaling pathwayMB, medulloblastomaMedulloblastomaPK, pharmacokineticPTCH, patchedSAR, structure?activity relationshipSHH, Sonic hedgehogSMO, smoothenedTGI, tumor growth inhibitionWNT, winglesshERG, human ether-a-go-go-related genei.v., intravenous injectionp.o., per os
DOI
10.1016/j.apsb.2020.07.007
PMID
33643826
发布时间
2021-03-03
- 浏览6
Acta pharmaceutica Sinica. B
2021年11卷2期
488-504页
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