换一批A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.
第一作者：
Toni M,Delorey
第一单位：
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
作者：
Toni M,Delorey [1]
;
Carly G K,Ziegler [2]
;
Graham,Heimberg [1]
;
Rachelly,Normand [3]
;
Yiming,Yang [4]
;
Asa,Segerstolpe [1]
;
Domenic,Abbondanza [1]
;
Stephen J,Fleming [5]
;
Ayshwarya,Subramanian [1]
;
Daniel T,Montoro [6]
;
Karthik A,Jagadeesh [1]
;
Kushal K,Dey [7]
;
Pritha,Sen [8]
;
Michal,Slyper [1]
;
Yered H,Pita-Juárez [9]
;
Devan,Phillips [1]
;
Zohar,Bloom-Ackerman [10]
;
Nick,Barkas [11]
;
Andrea,Ganna [12]
;
James,Gomez [10]
;
Erica,Normandin [13]
;
Pourya,Naderi [14]
;
Yury V,Popov [15]
;
Siddharth S,Raju [16]
;
Sebastian,Niezen [15]
;
Linus T-Y,Tsai [17]
;
Katherine J,Siddle [18]
;
Malika,Sud [1]
;
Victoria M,Tran [10]
;
Shamsudheen K,Vellarikkal [19]
;
Liat,Amir-Zilberstein [1]
;
Deepak S,Atri [19]
;
Joseph,Beechem [20]
;
Olga R,Brook [21]
;
Jonathan,Chen [22]
;
Prajan,Divakar [20]
;
Phylicia,Dorceus [1]
;
Jesse M,Engreitz [23]
;
Adam,Essene [24]
;
Donna M,Fitzgerald [25]
;
Robin,Fropf [20]
;
Steven,Gazal [26]
;
Joshua,Gould [11]
;
John,Grzyb [27]
;
Tyler,Harvey [1]
;
Jonathan,Hecht [28]
;
Tyler,Hether [20]
;
Judit,Jane-Valbuena [1]
;
Michael,Leney-Greene [6]
;
Hui,Ma [4]
;
Cristin,McCabe [1]
;
Daniel E,McLoughlin [25]
;
Eric M,Miller [20]
;
Christoph,Muus [29]
;
Mari,Niemi [30]
;
Robert,Padera [31]
;
Liuliu,Pan [20]
;
Deepti,Pant [24]
;
Carmel,Pe'er [1]
;
Jenna,Pfiffner-Borges [6]
;
Christopher J,Pinto [32]
;
Jacob,Plaisted [27]
;
Jason,Reeves [20]
;
Marty,Ross [20]
;
Melissa,Rudy [6]
;
Erroll H,Rueckert [20]
;
Michelle,Siciliano [27]
;
Alexander,Sturm [10]
;
Ellen,Todres [1]
;
Avinash,Waghray [33]
;
Sarah,Warren [20]
;
Shuting,Zhang [10]
;
Daniel R,Zollinger [20]
;
Lisa,Cosimi [34]
;
Rajat M,Gupta [19]
;
Nir,Hacohen [35]
;
Winston,Hide [36]
;
Alkes L,Price [7]
;
Jayaraj,Rajagopal [25]
;
Purushothama Rao,Tata [37]
;
Stefan,Riedel [28]
;
Gyongyi,Szabo [38]
;
Timothy L,Tickle [39]
;
Deborah,Hung [40]
;
Pardis C,Sabeti [41]
;
Richard,Novak [42]
;
Robert,Rogers [43]
;
Donald E,Ingber [44]
;
Z Gordon,Jiang [15]
;
Dejan,Juric [32]
;
Mehrtash,Babadi [5]
;
Samouil L,Farhi [1]
;
James R,Stone [45]
;
Ioannis S,Vlachos [9]
;
Isaac H,Solomon [27]
;
Orr,Ashenberg [1]
;
Caroline B M,Porter [1]
;
Bo,Li [46]
;
Alex K,Shalek [47]
;
Alexandra-Chloé,Villani [48]
;
Orit,Rozenblatt-Rosen [49]
;
Aviv,Regev [50]
作者单位：
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.
[1]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA 02115, USA.;Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.;Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.
[2]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.;Harvard Medical School, Boston, MA 02115, USA.;Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[3]
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.;Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
[4]
Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.;Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[5]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[6]
Department of Epidemiology, Harvard School of Public Health.
[7]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
[8]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Harvard Medical School, Boston, MA 02115, USA.;Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.;Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.;Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
[9]
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[10]
Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
[11]
Institute for Molecular Medicine Finland, Helsinki, Finland.;Analytical & Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
[12]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Harvard Medical School, Boston, MA 02115, USA.
[13]
Harvard Medical School, Boston, MA 02115, USA.;Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.;Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.
[14]
Harvard Medical School, Boston, MA 02115, USA.;Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.;Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
[15]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.;FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
[16]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Harvard Medical School, Boston, MA 02115, USA.;Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.;Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115.;Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, MA 02115, USA.
[17]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
[18]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
[19]
NanoString Technologies Inc., Seattle, WA 98109, USA.
[20]
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
[21]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
[22]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Genetics and BASE Initiative, Stanford University School of Medicine.
[23]
Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.;Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115.;Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, MA 02115, USA.
[24]
Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
[25]
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[26]
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
[27]
Harvard Medical School, Boston, MA 02115, USA.;Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
[28]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
[29]
Institute for Molecular Medicine Finland, Helsinki, Finland.
[30]
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.;Harvard-MIT Division of Health Sciences and Technology, Cambridge MA.;Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
[31]
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.;Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
[32]
Harvard Stem Cell Institute, Cambridge, MA, USA.;Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
[33]
Infectious Diseases Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
[34]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.;Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
[35]
Harvard Medical School, Boston, MA 02115, USA.;Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.;Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.;Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
[36]
Duke University School of Medicine, Durham, NC.
[37]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Harvard Medical School, Boston, MA 02115, USA.;Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.
[38]
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.;Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
[39]
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.;Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
[40]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.;Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.;Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.
[41]
Wyss Institute for Biologically Inspired Engineering, Harvard University.
[42]
Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.;Massachusetts General Hospital, MA 02114, USA.
[43]
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.;Wyss Institute for Biologically Inspired Engineering, Harvard University.;Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA USA.
[44]
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
[45]
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.;Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
[46]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA 02115, USA.;Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.;Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.;Harvard Medical School, Boston, MA 02115, USA.;Harvard Stem Cell Institute, Cambridge, MA, USA.;Program in Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[47]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.;Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.;Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.;Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
[48]
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.;Current address: Genentech, 1 DNA Way, South San Francisco, CA, USA.
[49]
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.;Current address: Genentech, 1 DNA Way, South San Francisco, CA, USA.
[50]
DOI
10.1101/2021.02.25.430130
PMID
33655247
发布时间
2023-11-10
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