Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.

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第一作者： Maciej,Cieśla

第一单位： Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden.

作者： Maciej,Cieśla ^[1] ; Phuong Cao Thi,Ngoc ^[1] ; Eugenia,Cordero ^[2] ; Álvaro Sejas,Martinez ^[1] ; Mikkel,Morsing ^[2] ; Sowndarya,Muthukumar ^[1] ; Giulia,Beneventi ^[1] ; Magdalena,Madej ^[1] ; Roberto,Munita ^[1] ; Terese,Jönsson ^[1] ; Kristina,Lövgren ^[3] ; Anna,Ebbesson ^[3] ; Björn,Nodin ^[3] ; Ingrid,Hedenfalk ^[3] ; Karin,Jirström ^[3] ; Johan,Vallon-Christersson ^[3] ; Gabriella,Honeth ^[3] ; Johan,Staaf ^[3] ; Danny,Incarnato ^[4] ; Kristian,Pietras ^[2] ; Ana,Bosch ^[5] ; Cristian,Bellodi ^[6]

作者单位： Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden. ^[1] Division of Translational Cancer Research, Department of Laboratory Medicine, Faculty of Medicine, Lund University, 22363 Lund, Sweden. ^[2] Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden. ^[3] Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands. ^[4] Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden. Electronic address: ana.bosch_campos@med.lu.se. ^[5] Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden. Electronic address: cristian.bellodi@med.lu.se. ^[6]

关键词 DRP1 MYC SF3A3 alternative splicing cancer plasticity cancer stem cells eIF3D mitochondrial dynamics translation control triple-negative breast cancer