Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.

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作者： Elena,Restelli ^[1] ; Vanessa,Capone ^[2] ; Manuela,Pozzoli ^[1] ; Davide,Ortolan ^[1] ; Elena,Quaglio ^[1] ; Alessandro,Corbelli ^[3] ; Fabio,Fiordaliso ^[3] ; Galina V,Beznoussenko ^[4] ; Vladimiro,Artuso ^[5] ; Ignazio,Roiter ^[6] ; Michele,Sallese ^[2] ; Roberto,Chiesa ^[7]

作者单位： Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. ^[1] Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti, Italy; Center for Advanced Studies and Technology (CAST), University G. D'Annunzio, Chieti, Italy. ^[2] Bio-Imaging Unit, Department of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. ^[3] IFOM-FIRC Institute of Molecular Oncology, Milan, Italy. ^[4] ULSS 3 Serenissima, Venice, Italy. ^[5] ULSS 2 Marca Trevigiana, Ca' Foncello Hospital, Treviso, Italy. ^[6] Laboratory of Prion Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. Electronic address: roberto.chiesa@marionegri.it. ^[7]

关键词 Src family kinase genetic prion disease prion protein protein misfolding protein trafficking

主题词动物(Animals);细胞, 培养的(Cells, Cultured);克-亚综合征(Creutzfeldt-Jakob Syndrome);疾病模型, 动物(Disease Models, Animal);内质网(Endoplasmic Reticulum);酶激活(Enzyme Activation);Gerstmann-Straussler-Scheinker病(Gerstmann-Straussler-Scheinker Disease);高尔基体(Golgi Apparatus);人类(Humans);失眠症, 致死性家族性(Insomnia, Fatal Familial);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交CBA(Mice, Inbred CBA);小鼠, 转基因(Mice, Transgenic);突变(Mutation);蛋白质折叠(Protein Folding);分泌途径(Secretory Pathway);src族激酶类(src-Family Kinases)

DOI 10.1016/j.jbc.2021.100490

PMID 33662396

发布时间 2024-08-12

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The Journal of biological chemistry

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Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.

The Journal of biological chemistry

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The Journal of biological chemistry

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Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.

The Journal of biological chemistry

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The Journal of biological chemistry

相关期刊

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