Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.-论文-万方医学网

第一作者： Marcela,Garzón-Tituaña

第一单位： Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.

作者： Marcela,Garzón-Tituaña ^[1] ; José L,Sierra-Monzón ^[1] ; Laura,Comas ^[2] ; Llipsy,Santiago ^[3] ; Tatiana,Khaliulina-Ushakova ^[1] ; Iratxe,Uranga-Murillo ^[1] ; Ariel,Ramirez-Labrada ^[2] ; Elena,Tapia ^[1] ; Elena,Morte-Romea ^[1] ; Sonia,Algarate ^[4] ; Ludovic,Couty ^[1] ; Eric,Camerer ^[2] ; Phillip I,Bird ^[1] ; Cristina,Seral ^[5] ; Pilar,Luque ^[2] ; José R,Paño-Pardo ^[6] ; Eva M,Galvez ^[6] ; Julián,Pardo ^[7] ; Maykel,Arias ^[1]

作者单位： Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain. ^[1] Hospital Clínico Universitario Lozano Blesa, 50009, Zaragoza, Spain. ^[2] Instituto de Carboquímica ICB-CSIC, 50018, Zaragoza, Spain. ^[3] Animal Unit, University of Zaragoza, 50009, Zaragoza, Spain. ^[4] Department of Biochemistry and Molecular and Cell Biology and Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, 50009, Zaragoza, Spain. ^[5] INSERM U970, Paris Cardiovascular Research Centre, Université de Paris, 75015, Paris, France. ^[6] Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, 3800, Clayton VIC, Australia. ^[7] Aragon I+D Foundation (ARAID), 50018, Zaragoza, Spain. ^[8] Nanoscience Institute of Aragon (INA), University of Zaragoza, 50018, Zaragoza, Spain. ^[9]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);动物(Animals);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);颗粒酶类(Granzymes);人类(Humans);炎症介导素类(Inflammation Mediators);白细胞介素6(Interleukin-6);杀伤细胞, 天然(Killer Cells, Natural);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);中年人(Middle Aged);分子靶向治疗(Molecular Targeted Therapy);腹膜炎(Peritonitis);脓毒症(Sepsis);舍平类(Serpins);Toll样受体4(Toll-Like Receptor 4)

DOI 10.7150/thno.49288

PMID 33664861

发布时间 2023-11-10

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Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.

Theranostics

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Theranostics

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Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.

Theranostics

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Theranostics

相关期刊

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