Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice.

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第一作者： Macarena,Tejos-Bravo

第一单位： Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Independencia, 8380492, Santiago, Chile.

作者： Macarena,Tejos-Bravo ^[1] ; Robert H,Oakley ^[2] ; Shannon D,Whirledge ^[2] ; Wladimir A,Corrales ^[1] ; Juan P,Silva ^[1] ; Gonzalo,García-Rojo ^[1] ; Jorge,Toledo ^[3] ; Wendy,Sanchez ^[4] ; Luciano,Román-Albasini ^[4] ; Esteban,Aliaga ^[1] ; Felipe,Aguayo ^[5] ; Felipe,Olave ^[1] ; Vinicius,Maracaja-Coutinho ^[1] ; John A,Cidlowski ^[6] ; Jenny L,Fiedler ^[2]

作者单位： Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Independencia, 8380492, Santiago, Chile. ^[1] Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, 27709, USA. ^[2] Carrera de Odontología. Facultad de Ciencias, Universidad de La Serena, La Serena, Chile. ^[3] Laboratory of Scientific Image Analysis (SCIAN-Lab), Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8380453, Chile. ^[4] Department of Kinesiology and the Neuropsychology and Cognitive Neurosciences Research Center (CINPSI-Neurocog), Faculty of Health Sciences, Universidad Católica del Maule, Talca, Chile. ^[5] Advanced Center for Chronic Diseases -ACCDiS. Faculty of Chemical and Pharmaceutical Sciences. Department of Biochemistry and Molecular Biology. Universidad de Chile, Independencia, 8380492, Santiago, Chile. ^[6]

关键词 Dendrites Dendritic spines Glucocorticoid receptor Glucocorticoids, (GCs)Hippocampus Neuroplasticity Sex Transcription factor, (TF)glucocorticoid response elements, (GREs)hypothalamic-pituitary-adrenal, (HPA)miRNAs microRNA, (miRNA)

DOI 10.1016/j.ynstr.2021.100306

PMID 33665240

发布时间 2021-03-06

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Neurobiology of stress

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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice.

Neurobiology of stress

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Neurobiology of stress

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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice.

Neurobiology of stress

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Neurobiology of stress

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