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Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE.

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第一作者： Xiuping,Sun

第一单位： NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS), Beijing, China.

作者： Xiuping,Sun ^[1] ; Xuan,Yu ^[1] ; Ling,Zhang ^[1] ; Wenjie,Zhao ^[1] ; Manshi,Wang ^[1] ; Yu,Zhang ^[1] ; Xianglei,Li ^[1] ; Ran,Gao ^[1] ; Ludivine S,Breger ^[2] ; Sandra,Dovero ^[2] ; Gregory,Porras ^[2] ; Pierre-Olivier,Fernagut ^[3] ; Benjamin,Dehay ^[2] ; Erwan,Bezard ^[4] ; Chuan,Qin ^[1]

作者单位： NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS), Beijing, China. ^[1] Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France. ^[2] Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France.;Université de Poitiers, Laboratoire de Neurosciences Expérimentales et Cliniques, INSERM UMR_S 1084, Poitiers, France. ^[3] NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS), Beijing, China.;Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France. ^[4]

关键词 Mouse Parkinson's disease Synucleinopathy Woodchuck hepatitis virus post-transcriptional regulatory element

DOI 10.1016/j.heliyon.2021.e06302

PMID 33665452

发布时间 2021-03-06

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Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE.

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Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE.

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