换一批
换一批Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.
第一作者：
Zhipei,Sang
第一单位：
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, 473061, China; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. Electronic address: sangzhipei@126.com.
作者：
主题词
乙酰胆碱酯酶(Acetylcholinesterase);阿尔茨海默病(Alzheimer Disease);胺类(Amines);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);抗氧化剂(Antioxidants);结合部位(Binding Sites);细胞存活(Cell Survival);查耳酮(Chalcone);药物设计(Drug Design);人类(Humans);动力学(Kinetics);金属(Metals);单胺氧化酶(Monoamine Oxidase);神经保护药(Neuroprotective Agents);PC12细胞(PC12 Cells);大鼠(Rats);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.ejmech.2021.113310
PMID
33667847
发布时间
2021-04-22
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