Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients.

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第一作者： Jue,Wang

第一单位： Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.

作者： Jue,Wang ^[1] ; Laura,Hertz ^[2] ; Sandra,Ruppenthal ^[3] ; Wassim,El Nemer ^[3] ; Philippe,Connes ^[4] ; Jeroen S,Goede ^[5] ; Anna,Bogdanova ^[6] ; Lutz,Birnbaumer ^[6] ; Lars,Kaestner ^[7]

作者单位： Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. ^[1] Theoretical Medicine and Biosciences, Saarland University, 66421 Homburg, Germany. ^[2] Experimental Physics, Dynamics of Fluids, Saarland University, 66123 Saarbrücken, Germany. ^[3] Gynaecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, 66421 Homburg, Germany. ^[4] Etablissement Français du Sang PACA-Corse, Aix Marseille Université, EFS, CNRS, ADES, 13005 Marseille, France. ^[5] Laboratoire d'Excellence GR-Ex, 75015 Paris, France. ^[6] Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Teal, University Claude Bernard Lyon 1, 69008 Lyon, France. ^[7] Division of Oncology and Hematology, Kantonsspital Winterthur, CH-8401 Winterthur, Switzerland. ^[8] Red Blood Cell Research Group, Institute of Veterinary Physiology, University of Zürich, CH-8057 Zürich, Switzerland. ^[9] Institute of Biomedical Research (BIOMED), Catholic University of Argentina, C1107AFF Buenos Aires, Argentina. ^[10] Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. ^[11]

关键词 CaV2.1 G protein signaling Gárdos channel LPA receptor MAP kinase TRPC6 erythrocytes protein kinase Cα sickle cell disease transgenic mice

主题词贫血, 镰状细胞性(Anemia, Sickle Cell);动物(Animals);钙(Calcium);钙通道, N型(Calcium Channels, N-Type);钙信号(Calcium Signaling);红细胞(Erythrocytes);GTP结合蛋白质类(GTP-Binding Proteins);人类(Humans);溶血磷脂素类(Lysophospholipids);MAP激酶信号系统(MAP Kinase Signaling System);小鼠(Mice);模型, 生物学(Models, Biological);蛋白激酶C(Protein Kinase C);组织供者(Tissue Donors)

DOI 10.3390/cells10020456

PMID 33672679

发布时间 2023-11-10

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2021年10卷2期

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