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Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.

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第一作者： Drew,Neavin

第一单位： Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.

作者： Drew,Neavin ^[1] ; Quan,Nguyen ^[2] ; Maciej S,Daniszewski ^[3] ; Helena H,Liang ^[4] ; Han Sheng,Chiu ^[2] ; Yong Kiat,Wee ^[1] ; Anne,Senabouth ^[1] ; Samuel W,Lukowski ^[2] ; Duncan E,Crombie ^[4] ; Grace E,Lidgerwood ^[3] ; Damián,Hernández ^[3] ; James C,Vickers ^[5] ; Anthony L,Cook ^[5] ; Nathan J,Palpant ^[2] ; Alice,Pébay ^[3] ; Alex W,Hewitt ^[6] ; Joseph E,Powell ^[7]

作者单位： Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia. ^[1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. ^[2] Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.;Department of Surgery, The University of Melbourne, Melbourne, Australia.;Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Australia. ^[3] Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.;Department of Surgery, The University of Melbourne, Melbourne, Australia. ^[4] Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Australia. ^[5] Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.;Department of Surgery, The University of Melbourne, Melbourne, Australia.;School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. ^[6] Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia. j.powell@garvan.org.au.;UNSW Cellular Genomics Futures Institute, School of Medical Sciences, University of New South Wales, Sydney, Australia. j.powell@garvan.org.au. ^[7]

关键词 Expression quantitative trait loci (eQTLs)Induced pluripotent stem cells (iPSCs)Single cell RNA-sequencing (scRNA-seq)