Synthesis and preclinical evaluation of [<sup>11</sup>C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain.

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作者： Naoyuki,Obokata ^[1] ; Chie,Seki ^[2] ; Takeshi,Hirata ^[3] ; Jun,Maeda ^[4] ; Hideki,Ishii ^[2] ; Yuji,Nagai ^[1] ; Takehiko,Matsumura ^[5] ; Misae,Takakuwa ^[1] ; Hajime,Fukuda ^[2] ; Takafumi,Minamimoto ^[2] ; Kazunori,Kawamura ^[2] ; Ming-Rong,Zhang ^[1] ; Tatsuo,Nakajima ^[5] ; Takeaki,Saijo ^[5] ; Makoto,Higuchi ^[2]

作者单位： Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. ^[1] Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa, 227-0033, Japan. ^[2] Department of Molecular Neuroimaging, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan. ^[3] Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. seki.chie@qst.go.jp. ^[4] Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. ^[5]

关键词 Occupancy PDE7 Positron emission tomography Quantification [11C]MTP38