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Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production.

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第一作者： Soumya R,Mohapatra

第一单位： DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

作者： Soumya R,Mohapatra ^[1] ; Ahmed,Sadik ^[1] ; Suraj,Sharma ^[2] ; Gernot,Poschet ^[3] ; Hagen M,Gegner ^[3] ; Tobias V,Lanz ^[4] ; Philippe,Lucarelli ^[5] ; Ursula,Klingmüller ^[6] ; Michael,Platten ^[7] ; Ines,Heiland ^[2] ; Christiane A,Opitz ^[8]

作者单位： DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[1] Department of Arctic and Marine Biology, UiT The Arctic University of Norway, Tromsø, Norway. ^[2] Centre for Organismal Studies (COS), University of Heidelberg, Heidelberg, Germany. ^[3] DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences (MCTN), Heidelberg University, Mannheim, Germany.;Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States. ^[4] Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[5] Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. ^[6] DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences (MCTN), Heidelberg University, Mannheim, Germany. ^[7] DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, Heidelberg, Germany. ^[8]

关键词 AHR activity TDO2 hallucination hypoxia liver regulation tryptamine tryptophan