Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.

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作者： Karsten,Bach ^[1] ; Sara,Pensa ^[2] ; Marija,Zarocsinceva ^[3] ; Katarzyna,Kania ^[1] ; Julie,Stockis ^[3] ; Silvain,Pinaud ^[3] ; Kyren A,Lazarus ^[4] ; Mona,Shehata ^[2] ; Bruno M,Simões ^[2] ; Alice R,Greenhalgh ^[2] ; Sacha J,Howell ^[1] ; Robert B,Clarke ^[3] ; Carlos,Caldas ^[5] ; Timotheus Y F,Halim ^[6] ; John C,Marioni ^[6] ; Walid T,Khaled ^[6]

作者单位： University of Cambridge, Department of Pharmacology, Cambridge, UK. ^[1] Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. ^[2] Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK. ^[3] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ^[4] Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK. ^[5] Manchester Breast Centre, Oglesby Cancer Research Building, University of Manchester, Manchester, UK. ^[6] Department of Medical Oncology, Christie NHS Foundation Trust, Manchester, UK. ^[7] Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. John.Marioni@cruk.cam.ac.uk. ^[8] Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. John.Marioni@cruk.cam.ac.uk. ^[9] European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK. John.Marioni@cruk.cam.ac.uk. ^[10] University of Cambridge, Department of Pharmacology, Cambridge, UK. wtk22@cam.ac.uk. ^[11] Cancer Research UK, Cambridge Cancer Centre, Cambridge, UK. wtk22@cam.ac.uk. ^[12] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. wtk22@cam.ac.uk. ^[13]