首页> The EMBO journal> Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.

Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.

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第一作者： Andreas,Lackner

第一单位： Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter, Vienna, Austria.

作者： Andreas,Lackner ^[1] ; Robert,Sehlke ^[2] ; Marius,Garmhausen ^[2] ; Giuliano,Giuseppe Stirparo ^[3] ; Michelle,Huth ^[1] ; Fabian,Titz-Teixeira ^[2] ; Petra,van der Lelij ^[1] ; Julia,Ramesmayer ^[1] ; Henry F,Thomas ^[1] ; Meryem,Ralser ^[4] ; Laura,Santini ^[1] ; Elena,Galimberti ^[1] ; Mihail,Sarov ^[5] ; A Francis,Stewart ^[6] ; Austin,Smith ^[3] ; Andreas,Beyer ^[7] ; Martin,Leeb ^[1]

作者单位： Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter, Vienna, Austria. ^[1] Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. ^[2] Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.;Living Systems Institute, University of Exeter, Exeter, UK. ^[3] Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. ^[4] Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. ^[5] Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.;Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany. ^[6] Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.;Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. ^[7]

关键词 exit from na?ve pluripotency haploid ES cells na?ve to formative transition signalling systems biology

医学主题词动物(Animals);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);基因表达调控, 发育期(Gene Expression Regulation, Developmental);基因调控网络(Gene Regulatory Networks);小鼠(Mice)

DOI 10.15252/embj.2020105776

PMID 33687089

发布时间 2025-05-30

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