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首页> Toxicology and applied pharmacology> Notoginsenoside R1 alleviates TEGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy.

Notoginsenoside R1 alleviates TEGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy.

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作者： Konghuai,Wang ^[1] ; Danni,Wu ^[1] ; Xuekun,Ren ^[1] ; Qihao,Yu ^[1] ; Ruona,Liu ^[1] ; Shengbin,Huang ^[2] ; Yihuai,Pan ^[3] ; Shufan,Zhao ^[4]

作者单位： Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. ^[1] Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: huangsb003@wmu.edu.cn. ^[2] Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: yihuaipan@wmu.edu.cn. ^[3] Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: shufan.zhao@hotmail.com. ^[4]

关键词 Apoptosis Mitochondria Mitophagy Notoginsenoside R1 Oxidative stress TEGDMA

主题词动物(Animals);抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);细胞系(Cell Line);酶激活(Enzyme Activation);人参皂甙类(Ginsenosides);小鼠(Mice);线粒体(Mitochondria);NF-E2相关因子2(NF-E2-Related Factor 2);成牙质细胞(Odontoblasts);氧化性应激(Oxidative Stress);磷酰化(Phosphorylation);聚乙烯二醇类(Polyethylene Glycols);聚甲基丙烯酸类(Polymethacrylic Acids);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction)

DOI 10.1016/j.taap.2021.115482

PMID 33689844

发布时间 2021-05-10

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Toxicology and applied pharmacology

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