Blockade of 6-phosphogluconate dehydrogenase generates CD8<sup>+</sup> effector T cells with enhanced anti-tumor function.-论文-万方医学网

作者： Saeed,Daneshmandi ^[1] ; Teresa,Cassel ^[2] ; Penghui,Lin ^[2] ; Richard M,Higashi ^[3] ; Gerburg M,Wulf ^[4] ; Vassiliki A,Boussiotis ^[4] ; Teresa W-M,Fan ^[5] ; Pankaj,Seth ^[6]

作者单位： Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Division of Interdisciplinary Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. ^[1] Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY 40536, USA. ^[2] Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY 40536, USA; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA. ^[3] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. ^[4] Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY 40536, USA; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA. Electronic address: teresa.fan@uky.edu. ^[5] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Division of Interdisciplinary Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: sethpankaj829@gmail.com. ^[6]

主题词 6-氨基烟酰胺(6-Aminonicotinamide);动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);颗粒酶类(Granzymes);人类(Humans);免疫疗法(Immunotherapy);单核细胞增生利斯特菌(Listeria monocytogenes);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);线粒体(Mitochondria);肿瘤(Neoplasms);磷酸戊糖途径(Pentose Phosphate Pathway);磷酸葡糖脱氢酶(Phosphogluconate Dehydrogenase);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction);超氧化物歧化酶(Superoxide Dismutase);移植, 异种(Transplantation, Heterologous)

DOI 10.1016/j.celrep.2021.108831

PMID 33691103

发布时间 2024-09-23

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Blockade of 6-phosphogluconate dehydrogenase generates CD8<sup>+</sup> effector T cells with enhanced anti-tumor function.

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Blockade of 6-phosphogluconate dehydrogenase generates CD8<sup>+</sup> effector T cells with enhanced anti-tumor function.

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Cell reports

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