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Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo.

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第一作者： Simone,Mester

第一单位： Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.;Department of Pharmacology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

作者： Simone,Mester ^[1] ; Mitchell,Evers ^[2] ; Saskia,Meyer ^[3] ; Jeannette,Nilsen ^[1] ; Victor,Greiff ^[4] ; Inger,Sandlie ^[5] ; Jeanette,Leusen ^[2] ; Jan Terje,Andersen ^[1]

作者单位： Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.;Department of Pharmacology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[1] Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[2] Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway. ^[3] Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway. ^[4] Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.;Department of Biosciences, University of Oslo, Oslo, Norway. ^[5]

关键词 Immunoglobulin A (IgA)albumin-binding-domain (ABD)half-life human FcRn transgenic mice human serum albumin (HSA)the neonatal Fc receptor (FcRn)