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Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis.

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第一作者： Cong,Liu

第一单位： Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.;Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

作者： Cong,Liu ^[1] ; Milena,Schönke ^[1] ; Enchen,Zhou ^[1] ; Zhuang,Li ^[1] ; Sander,Kooijman ^[1] ; Mariëtte R,Boon ^[1] ; Mikael,Larsson ^[2] ; Kristina,Wallenius ^[2] ; Niek,Dekker ^[3] ; Louise,Barlind ^[3] ; Xiao-Rong,Peng ^[2] ; Yanan,Wang ^[4] ; Patrick C N,Rensen ^[4]

作者单位： Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.;Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. ^[1] Cardiovascular, Renal and Metabolism, AstraZeneca BioPharmaceutical R&D, Gothenburg, Sweden. ^[2] Discovery Sciences, AstraZeneca BioPharmaceutical R&D, Gothenburg, Sweden. ^[3] Department of Medicine, Division of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.;Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.;Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China. ^[4]

关键词 Adipose-liver axis Atherosclerotic cardiovascular disease Brown adipose tissue Dyslipidaemia Lipoprotein metabolism