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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.

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第一作者： Laurie B,Schenkel

第一单位： Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; MOMA Therapeutics, Cambridge, MA 02142, USA.

作者： Laurie B,Schenkel ^[1] ; Jennifer R,Molina ^[2] ; Kerren K,Swinger ^[3] ; Ryan,Abo ^[4] ; Danielle J,Blackwell ^[5] ; Alvin Z,Lu ^[2] ; Anne E,Cheung ^[6] ; W David,Church ^[5] ; Kaiko,Kunii ^[2] ; Kristy G,Kuplast-Barr ^[2] ; Christina R,Majer ^[5] ; Elena,Minissale ^[2] ; Jan-Rung,Mo ^[2] ; Mario,Niepel ^[2] ; Christopher,Reik ^[7] ; Yue,Ren ^[5] ; Melissa M,Vasbinder ^[5] ; Tim J,Wigle ^[5] ; Victoria M,Richon ^[8] ; Heike,Keilhack ^[2] ; Kevin W,Kuntz ^[9]

作者单位： Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; MOMA Therapeutics, Cambridge, MA 02142, USA. ^[1] Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA. ^[2] Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Xilio Therapeutics, Waltham, MA 02451, USA. ^[3] Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Obsidian Therapeutics, Cambridge, MA 02138, USA. ^[4] Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA. ^[5] Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; A2Empowerment, Arlington, MA 02474, USA. ^[6] Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Bain & Company, Boston, MA 02116, USA. ^[7] Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA. ^[8] Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA. Electronic address: kkuntz@ribontx.com. ^[9]

关键词 PARP14 inhibitor chemical probe immuno-oncology immunosuppression macrophage polarization monoPARP poly(ADP-ribose) polymerase 14 (PARP14)