New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (-)-fenchone hydrazonesv.

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作者： Olga I,Yarovaya ^[1] ; Kseniya S,Kovaleva ^[1] ; Anna A,Zaykovskaya ^[2] ; Liudmila N,Yashina ^[2] ; Nadezda S,Scherbakova ^[2] ; Dmitry N,Scherbakov ^[2] ; Sophia S,Borisevich ^[3] ; Fedor I,Zubkov ^[4] ; Alexandra S,Antonova ^[4] ; Roman Yu,Peshkov ^[5] ; Ilia V,Eltsov ^[5] ; Oleg V,Pyankov ^[2] ; Rinat A,Maksyutov ^[2] ; Nariman F,Salakhutdinov ^[1]

作者单位： N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, Novosibirsk 630090, Russia. ^[1] State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, Koltsovo, Novosibirsk Region 630559, Russia. ^[2] Ufa Institute of Chemistry, Ufa Federal Research Center, RAS, Octyabrya pr., 71, Ufa 450054, Russia. ^[3] Organic Chemistry Department, Faculty of Science, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow 117198, Russia. ^[4] Novosibirsk State University, Pirogova St. 1, Novosibirsk 630090, Russia. ^[5]

关键词 Antiviral HFRS Hantavirus Isoindole Terpene

主题词动物(Animals);抗病毒药(Antiviral Agents);衣壳蛋白质类(Capsid Proteins);狗(Dogs);药物设计(Drug Design);HEK293细胞(HEK293 Cells);汉坦病毒(Hantaan virus);人类(Humans);腙类(Hydrazones);异吲哚类(Isoindoles);微生物敏感性试验(Microbial Sensitivity Tests);原冰片烷类(Norbornanes);蛋白质结合(Protein Binding);病毒核心蛋白质类(Viral Core Proteins)

DOI 10.1016/j.bmcl.2021.127926

PMID 33705902

发布时间 2021-09-21

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Bioorganic & medicinal chemistry letters

2021年40卷

127926页

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New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (-)-fenchone hydrazonesv.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

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New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (-)-fenchone hydrazonesv.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

相关期刊

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