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首页> Food chemistry> Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells.

Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells.

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作者： Pengzhan,Liu ^[1] ; Zhao,Yin ^[2] ; Min,Chen ^[3] ; Caihuan,Huang ^[3] ; Zhihui,Wu ^[4] ; Junqing,Huang ^[5] ; Shiyi,Ou ^[3] ; Jie,Zheng ^[6]

作者单位： School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, China. ^[1] Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, China; School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China. ^[2] Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. ^[3] Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China. ^[4] Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China. ^[5] Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. Electronic address: zhengjie@jnu.edu.cn. ^[6]

关键词 AKT/Nrf2 signaling pathway Cookies Mitochondria-mediated apoptosis Mitochondrial dysfunction Neurotoxicity Quercetin-methylglyoxal adduct

主题词动物(Animals);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞毒素类(Cytotoxins);人类(Humans);膜电位, 线粒体(Membrane Potential, Mitochondrial);线粒体(Mitochondria);PC12细胞(PC12 Cells);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);丙酮醛(Pyruvaldehyde);槲皮素(Quercetin);大鼠(Rats);信号传导(Signal Transduction)

DOI 10.1016/j.foodchem.2021.129424

PMID 33706136

发布时间 2021-04-07

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