Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control.

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第一作者： Qiang,Liu

第一单位： Twist Biopharma, South San Francisco, CA, USA.

作者： Qiang,Liu ^[1] ; Pankaj,Garg ^[1] ; Burcu,Hasdemir ^[2] ; Linya,Wang ^[1] ; Emily,Tuscano ^[3] ; Emily,Sever ^[1] ; Erica,Keane ^[1] ; Ana G Lujan,Hernandez ^[1] ; Tom Z,Yuan ^[1] ; Eric,Kwan ^[1] ; Joyce,Lai ^[1] ; Greg,Szot ^[1] ; Sreenivasan,Paruthiyil ^[1] ; Fumiko,Axelrod ^[4] ; Aaron,K Sato ^[4]

作者单位： Twist Biopharma, South San Francisco, CA, USA. ^[1] Alamar Biosciences, Fremont, CA, USA. ^[2] Catalyst Biosciences, South San Francisco, CA, USA. ^[3] Diabetes Center, University of California San Francisco, San Francisco, CA, USA. ^[4]

关键词 GPCR agonist antagonist glp-1 peptide glucose level panning phage display library

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);结合部位, 抗体(Binding Sites, Antibody);血糖(Blood Glucose);CHO细胞(CHO Cells);仓鼠属(Cricetulus);高通量筛选分析(High-Throughput Screening Assays);降血糖药(Hypoglycemic Agents);肠促胰岛素类(Incretins);配体(Ligands);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);肽库(Peptide Library);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);小鼠(Mice);大鼠(Rats)

DOI 10.1080/19420862.2021.1893425

PMID 33706686

发布时间 2024-02-26

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Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control.

mAbs

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Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control.

mAbs

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mAbs

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