首页> Angewandte Chemie (International ed. in English)> Complexation of an Antimicrobial Peptide by Large-Sized Macrocycles for Decreasing Hemolysis and Improving Stability.

Complexation of an Antimicrobial Peptide by Large-Sized Macrocycles for Decreasing Hemolysis and Improving Stability.

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第一作者： Junyi,Chen

第一单位： College of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China.;State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P. R. China.

作者： Junyi,Chen ^[1] ; Qingbin,Meng ^[2] ; Yadan,Zhang ^[2] ; Ming,Dong ^[3] ; Liang,Zhao ^[2] ; Yahan,Zhang ^[2] ; Longming,Chen ^[2] ; Yao,Chai ^[2] ; Zhao,Meng ^[2] ; Chenhong,Wang ^[2] ; Xueshun,Jia ^[4] ; Chunju,Li ^[5]

作者单位： College of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China.;State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P. R. China. ^[1] State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P. R. China. ^[2] Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, China. ^[3] College of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China. ^[4] College of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China.;Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, 300387, China. ^[5]

关键词 hemolysis host-guest complexation large-sized macrocycles metabolic stability peptides

主题词抗微生物阳离子肽类(Antimicrobial Cationic Peptides);杯芳烃类化合物(Calixarenes);大环化合物(Macrocyclic Compounds);分子结构(Molecular Structure);蛋白质稳定性(Protein Stability)

DOI 10.1002/anie.202102706

PMID 33709627

发布时间 2021-08-09

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