Structural mechanism underlying ligand binding and activation of PPARγ.

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作者： Jinsai,Shang ^[1] ; Douglas J,Kojetin ^[2]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. ^[1] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: dkojetin@scripps.edu. ^[2]

关键词 NMR spectroscopy conformational selection encounter complex induced fit ligand binding mechanism nuclear receptor

主题词氨基酸取代(Amino Acid Substitution);结合部位(Binding Sites);人类(Humans);配体(Ligands);分子动力学模拟(Molecular Dynamics Simulation);PPARγ(PPAR gamma);蛋白质结合(Protein Binding)

DOI 10.1016/j.str.2021.02.006

PMID 33713599

发布时间 2022-09-03

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