Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury.

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作者： Xuhui,Ge ^[1] ; Pengyu,Tang ^[1] ; Yuluo,Rong ^[1] ; Dongdong,Jiang ^[1] ; Xiao,Lu ^[2] ; Chengyue,Ji ^[1] ; Jiaxing,Wang ^[1] ; Chenyu,Huang ^[3] ; Ao,Duan ^[1] ; Yang,Liu ^[4] ; Xinglin,Chen ^[5] ; Xichen,Chen ^[6] ; Zhiyang,Xu ^[6] ; Feng,Wang ^[6] ; Zibin,Wang ^[6] ; Xiaoyan,Li ^[6] ; Wene,Zhao ^[6] ; Jin,Fan ^[1] ; Wei,Liu ^[7] ; Guoyong,Yin ^[8] ; Weihua,Cai ^[9]

作者单位： Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. ^[1] Department of Orthopedics, Dongtai Hospital Affiliated to Nantong University, Yancheng, 224200, Jiangsu, China. ^[2] Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China. ^[3] Department of Orthopedics, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, 214002, Jiangsu, China. ^[4] Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. ^[5] Department of Analytical & Testing Center, Nanjing Medical University, Nanjing, 211166, Jiangsu, China. ^[6] Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: liuweiorth@njmu.edu.cn. ^[7] Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: guoyong_yin@sina.com. ^[8] Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: caiwhspine@sina.com. ^[9]

关键词 Blood-spinal-cord-barrier Endothelial-to-mesenchymal transition Mitochondria Spinal cord injury miR-155/SOCS6/p65

主题词内皮细胞(Endothelial Cells);人类(Humans);婴儿, 新生(Infant, Newborn);巨噬细胞(Macrophages);微RNAs(MicroRNAs);线粒体(Mitochondria);NF-κB(NF-kappa B);信号传导(Signal Transduction);脊髓损伤(Spinal Cord Injuries);细胞因子信号转导蛋白抑制因子(Suppressor of Cytokine Signaling Proteins)

DOI 10.1016/j.redox.2021.101932

PMID 33714739

发布时间 2022-05-31

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Redox biology

2021年41卷

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Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury.

Redox biology

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Redox biology

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Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury.

Redox biology

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Redox biology

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