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pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects.

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第一作者： Lindomar J C,Albuquerque

第一单位： Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André 09210-580, Brazil. Electronic address: lindomar.albuquerque@ufabc.edu.br.

作者： Lindomar J C,Albuquerque ^[1] ; Vladimir,Sincari ^[2] ; Alessandro,Jäger ^[2] ; Jan,Kucka ^[2] ; Jana,Humajova ^[3] ; Jan,Pankrac ^[4] ; Petr,Paral ^[4] ; Tomas,Heizer ^[4] ; Olga,Janouškova ^[2] ; Irina,Davidovich ^[5] ; Yeshayahu,Talmon ^[5] ; Pavla,Pouckova ^[3] ; Petr,Štěpánek ^[2] ; Ludek,Sefc ^[4] ; Martin,Hruby ^[2] ; Fernando C,Giacomelli ^[6] ; Eliézer,Jäger ^[7]

作者单位： Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André 09210-580, Brazil. Electronic address: lindomar.albuquerque@ufabc.edu.br. ^[1] Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic. ^[2] Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovska, 1, 120 00 Prague, Czech Republic. ^[3] Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, 120 00, Czech Republic. ^[4] Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology, Haifa 3200003, Israel. ^[5] Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André 09210-580, Brazil. ^[6] Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic. Electronic address: jager@imc.cas.cz. ^[7]

关键词 Antitumor activity Cardiotoxicity Doxorubicin Nanomedicine pH-responsive polymersomes