The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.

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作者： Terytty Yang,Li ^[1] ; Maroun Bou,Sleiman ^[1] ; Hao,Li ^[2] ; Arwen W,Gao ^[1] ; Adrienne,Mottis ^[1] ; Alexis Maximilien,Bachmann ^[1] ; Gaby,El Alam ^[1] ; Xiaoxu,Li ^[1] ; Ludger J E,Goeminne ^[1] ; Kristina,Schoonjans ^[1] ; Johan,Auwerx ^[2]

作者单位： Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. ^[1] Laboratory of Metabolic Signaling, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. ^[2]

主题词动物(Animals);人类(Humans);小鼠(Mice);秀丽新小杆线虫(Caenorhabditis elegans);漂亮新小杆线虫蛋白质类(Caenorhabditis elegans Proteins);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);组蛋白酰基转移酶(Histone Acetyltransferases);组蛋白脱甲基酶类(Histone Demethylases);长寿(Longevity);哺乳动物(Mammals);转录因子(Transcription Factors);CREB结合蛋白质(CREB-Binding Protein)

DOI 10.1038/s43587-020-00025-z

PMID 33718883

发布时间 2023-07-25

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Nature aging

2021年1卷2期

165-178页

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The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.

Nature aging

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Nature aging

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The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.

Nature aging

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Nature aging

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