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首页> Metabolism: clinical and experimental> Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.

Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.

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作者： Xinyu,Li ^[1] ; Shuanggang,Hu ^[1] ; Qinling,Zhu ^[1] ; Guangxin,Yao ^[1] ; Jufang,Yao ^[2] ; Jiaxing,Li ^[1] ; Yuan,Wang ^[1] ; Ying,Ding ^[1] ; Jia,Qi ^[1] ; Rui,Xu ^[1] ; Hanting,Zhao ^[1] ; Zhenyi,Zhu ^[1] ; Yanzhi,Du ^[1] ; Kang,Sun ^[1] ; Yun,Sun ^[3]

作者单位： Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China. ^[1] Animal Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China. ^[2] Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China. Electronic address: syun163@163.com. ^[3]

关键词 11β-Hydroxysteroid dehydrogenase type 1 BVT.2733 Cortisol Extracellular matrix Insulin resistance Polycystic ovary syndrome

主题词 11-β-羟甾脱氢酶1型(11-beta-Hydroxysteroid Dehydrogenase Type 1);动物(Animals);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);药物评价, 临床前(Drug Evaluation, Preclinical);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);人类(Humans);不育, 女(雌)性(Infertility, Female);胰岛素抗药性(Insulin Resistance);卵巢(Ovary);哌嗪类(Piperazines);多囊卵巢综合征(Polycystic Ovary Syndrome);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);磺胺类(Sulfonamides);噻唑类(Thiazoles)

DOI 10.1016/j.metabol.2021.154749

PMID 33722534

发布时间 2021-06-24

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