Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis.

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作者： Arne,Sahm ^[1] ; Matthias,Platzer ^[1] ; Philipp,Koch ^[2] ; Yoshiyuki,Henning ^[3] ; Martin,Bens ^[4] ; Marco,Groth ^[4] ; Hynek,Burda ^[5] ; Sabine,Begall ^[6] ; Saskia,Ting ^[5] ; Moritz,Goetz ^[7] ; Paul,Van Daele ^[7] ; Magdalena,Staniszewska ^[8] ; Jasmin Mona,Klose ^[9] ; Pedro Fragoso,Costa ^[9] ; Steve,Hoffmann ^[9] ; Karol,Szafranski ^[1] ; Philip,Dammann ^[2]

作者单位： Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany. ^[1] Core Facility Life Science Computing, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany. ^[2] Institute of Physiology, University Hospital, University of Duisburg-Essen, Essen, Germany. ^[3] Core Facility Sequencing, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany. ^[4] Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany. ^[5] Department of Game Management and Wildlife Biology, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences, Prague, Czech Republic. ^[6] Institute of Pathology and Neuropathology, University Hospital, University of Duisburg-Essen, Essen, Germany. ^[7] Department of Zoology, University of South Bohemia, České Budějovice, Czech Republic. ^[8] Department of Nuclear Medicine, University Hospital, University of Duisburg-Essen, Essen, Germany. ^[9] Central Animal Laboratory, University Hospital, University of Duisburg-Essen, Essen, Germany. ^[10]

关键词 ACTHR DHEA Fukomys chromosomes computational biology differential gene expression gene expression hypothalamic-pituitary-adrenal axis lifespan systems biology