Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial.
作者:
INSPIRATION Investigators [1]
;
Parham,Sadeghipour [2]
;
Azita H,Talasaz [3]
;
Farid,Rashidi [4]
;
Babak,Sharif-Kashani [5]
;
Mohammad Taghi,Beigmohammadi [6]
;
Mohsen,Farrokhpour [7]
;
Seyed Hashem,Sezavar [8]
;
Pooya,Payandemehr [9]
;
Ali,Dabbagh [10]
;
Keivan Gohari,Moghadam [11]
;
Sepehr,Jamalkhani [12]
;
Hossein,Khalili [13]
;
Mahdi,Yadollahzadeh [14]
;
Taghi,Riahi [8]
;
Parisa,Rezaeifar [15]
;
Ouria,Tahamtan [4]
;
Samira,Matin [4]
;
Atefeh,Abedini [4]
;
Somayeh,Lookzadeh [16]
;
Hamid,Rahmani [16]
;
Elnaz,Zoghi [17]
;
Keyhan,Mohammadi [18]
;
Pardis,Sadeghipour [18]
;
Homa,Abri [8]
;
Sanaz,Tabrizi [8]
;
Seyed Masoud,Mousavian [15]
;
Shaghayegh,Shahmirzaei [15]
;
Hooman,Bakhshandeh [10]
;
Ahmad,Amin [2]
;
Farnaz,Rafiee [19]
;
Elahe,Baghizadeh [19]
;
Bahram,Mohebbi [19]
;
Seyed Ehsan,Parhizgar [19]
;
Rasoul,Aliannejad [1]
;
Vahid,Eslami [19]
;
Alireza,Kashefizadeh [20]
;
Hessam,Kakavand [21]
;
Seyed Hossein,Hosseini [22]
;
Shadi,Shafaghi [23]
;
Samrand Fattah,Ghazi [18]
;
Atabak,Najafi [18]
;
David,Jimenez [6]
;
Aakriti,Gupta [7]
;
Mahesh V,Madhavan [10]
;
Sanjum S,Sethi [24]
;
Sahil A,Parikh [25]
;
Manuel,Monreal [26]
;
Naser,Hadavand [27]
;
Alireza,Hajighasemi [28]
;
Majid,Maleki [29]
;
Saeed,Sadeghian [27]
;
Gregory,Piazza [28]
;
Ajay J,Kirtane [27]
;
Benjamin W,Van Tassell [28]
;
Paul P,Dobesh [27]
;
Gregg W,Stone [28]
;
Gregory Y H,Lip [30]
;
Harlan M,Krumholz [19]
;
Samuel Z,Goldhaber [3]
;
Behnood,Bikdeli [19]
作者单位:
Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.
[1]
Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.
[2]
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
[3]
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
[4]
Tobacoo Prevention and control Research center, National Research institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[5]
Lung Transplantation Research Center, Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[6]
Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
[7]
Firouzgar hospital, Department of internal medicine, Iran University of Medical Sciences, Tehran, Iran.
[8]
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.
[9]
Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
[10]
Department of Anesthesiology, School of Medicine Anesthesiology Research Center Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[11]
School of Medicine, Department of Internal Medicine, Shariati Hospital, Tehran, Iran.
[12]
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
[13]
Department of Pharmacotherapy, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
[14]
Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
[15]
Chronic Respiratory Disease Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[16]
Department of Pharmacotherapy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
[17]
School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
[18]
Rajaie Cardiovascular Medical and Research Center, Iran university of Medical sciences, Tehran, Iran.
[19]
School of Medicine, Department of Pulmonary and Critical Care, Shariati Hospital, Tehran, Iran.
[20]
Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran.
[21]
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[22]
Shahid Dr Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[23]
Respiratory Department, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain.
[24]
Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain.
[25]
CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
[26]
Cardiovascular Research Foundation (CRF), New York, New York.
[27]
Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York.
[28]
Yale/YNHH Center for Outcomes Research & Evaluation, New Haven, Connecticut.
[29]
Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Universidad Católica de Murcia, Murcia, Spain.
[30]
Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
[31]
School of Pharmacy, Department of Pharmacotherapy and Outcome Science, Virginia Commonwealth University, Richmond, Virginia.
[32]
School of Pharmacy, Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
[33]
College of Pharmacy, University of Nebraska Medical Center, Omaha.
[34]
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
[35]
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.
[36]
Aalborg University, Aalborg, Denmark.
[37]
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
[38]
Department of Health Policy and Administration, Yale School of Public Health, New Haven, Connecticut.
[39]
主题词
老年人(Aged);抗凝药(Anticoagulants);用药计划表(Drug Administration Schedule);依诺肝素(Enoxaparin);体外膜氧合作用(Extracorporeal Membrane Oxygenation);女(雌)性(Female);出血(Hemorrhage);住院(Hospitalization);人类(Humans);重症监护病房(Intensive Care Units);伊朗(Iran);住院时间(Length of Stay);男(雄)性(Male);中年人(Middle Aged);比值比(Odds Ratio);氧吸入疗法(Oxygen Inhalation Therapy);肺栓塞(Pulmonary Embolism);血小板减少(Thrombocytopenia);血栓形成(Thrombosis);治疗结果(Treatment Outcome);静脉血栓形成(Venous Thrombosis)
DOI
10.1001/jama.2021.4152
PMID
33734299
发布时间
2021-09-20
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JAMA
JAMA
1620-1630页
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