GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape.

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作者： Matteo,Caforio ^[1] ; Cristina,Sorino ^[2] ; Ignazio,Caruana ^[3] ; Gerrit,Weber ^[1] ; Antonio,Camera ^[1] ; Loredana,Cifaldi ^[1] ; Biagio,De Angelis ^[4] ; Francesca,Del Bufalo ^[5] ; Alessia,Vitale ^[1] ; Bianca Maria,Goffredo ^[1] ; Rita,De Vito ^[6] ; Doriana,Fruci ^[6] ; Concetta,Quintarelli ^[7] ; Maurizio,Fanciulli ^[1] ; Franco,Locatelli ^[1] ; Valentina,Folgiero ^[8]

作者单位： Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. ^[1] Departement of Biochemical Sciences "A Rossi Fanelli", Sapienza University of Rome, Rome, Italy. ^[2] SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, Istituto Regina Elena Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, Italy. ^[3] Academic Department of Pediatrics (DPUO), IRCCS Bambino Gesù Children's Hospistal, Rome, Italy. ^[4] Department of Clical Sciences and Translational Medicine, University of Tor Vergata, Rome, Italy. ^[5] Division of Metabolism and Research Unit of Metabolic Biochemistry, IRCCS Bambino gesù Children's Hospital, Rome, Italy. ^[6] Department of Laboratories, Pathology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. ^[7] Departyment of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy. ^[8] Department of Pediatrics, Sapienza University of Rome, Rome, Italy. ^[9] Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy valentina.folgiero@opbg.net. ^[10]

关键词 -dioxygenase 3 adoptive immunotherapy indoleamine-pyrrole 2 natural killer T-cells neuroblastoma tumor microenvironment

主题词细胞系, 肿瘤(Cell Line, Tumor);共同培养技术(Coculture Techniques);神经节苷脂类(Gangliosides);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);吲哚胺-吡咯2,3-双加氧酶(Indoleamine-Pyrrole 2,3,-Dioxygenase);干扰素γ(Interferon-gamma);杀伤细胞, 天然(Killer Cells, Natural);淋巴细胞活化(Lymphocyte Activation);神经母细胞瘤(Neuroblastoma);信号传导(Signal Transduction);T淋巴细胞(T-Lymphocytes);肿瘤逃逸(Tumor Escape);肿瘤微环境(Tumor Microenvironment)

DOI 10.1136/jitc-2020-001502

PMID 33737337

发布时间 2021-12-17

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Journal for immunotherapy of cancer

2021年9卷3期

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GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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