Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies.

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作者： Andreas L,Gimpel ^[1] ; Georgios,Katsikis ^[2] ; Sha,Sha ^[3] ; Andrew John,Maloney ^[4] ; Moo Sun,Hong ^[5] ; Tam N T,Nguyen ^[1] ; Jacqueline,Wolfrum ^[1] ; Stacy L,Springs ^[1] ; Anthony J,Sinskey ^[5] ; Scott R,Manalis ^[5] ; Paul W,Barone ^[4] ; Richard D,Braatz ^[5]

作者单位： Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[1] Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. ^[2] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[3] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[4] Center for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[5] Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[6] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[7]

关键词 AAV CQAs adeno-associated virus critical quality attributes gene therapies process characterization process development process understanding viral vectors

DOI 10.1016/j.omtm.2021.02.010

PMID 33738328

发布时间 2021-03-21

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Molecular therapy. Methods & clinical development

2021年20卷

740-754页

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Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

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Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

相关期刊

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