Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties.

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作者： Manola,Moretti ^[1] ; Rosanna,La Rocca ^[2] ; Michela,Perrone Donnorso ^[2] ; Bruno,Torre ^[1] ; Claudio,Canale ^[3] ; Mario,Malerba ^[2] ; Gobind,Das ^[4] ; Rosa,Sottile ^[5] ; Cinzia,Garofalo ^[6] ; Adnane,Achour ^[7] ; Klas,Kärre ^[8] ; Ennio,Carbone ^[9] ; Enzo,Di Fabrizio ^[10]

作者单位： Single Molecule Imaging by Light Enhanced Spectroscopies Lab, King Abdullah University of Science and Technology, 23955-6900 Thuwal, Jeddah, Kingdom of Saudi Arabia. ^[1] Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. ^[2] Department of Physics, University of Genova, Via Dodecaneso 33, 16146 Genova, Italy. ^[3] Department of Physics, Khalifa University, P. O. Box 127788 Abu Dhabi, United Arab Emirates. ^[4] Katharine Hsu Lab, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States. ^[5] Department for Experimental and Clinical Medicine, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy. ^[6] Science for Life Laboratory, Department of Medicine, Solna, Karolinska Institute, and Division of Infectious Diseases, Karolinska University Hospital, 17176 Solna, Stockholm, Sweden. ^[7] Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Biomedicum Solnavägen 9, 17165 Solna, Stockholm, Sweden. ^[8] Dipartimento Medicina di Precisione, Università della Campania, via L. De Crecchio, 7, 80138 Naples, Italy. ^[9] Department of Applied Physics, Polytechnic University of Turin, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy. ^[10]

关键词 AFM MHC-I clustering cancer cells nanomechanical properties single molecule force spectroscopy

主题词抗原呈递细胞(Antigen-Presenting Cells);聚类分析(Cluster Analysis);结肠(Colon);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);组织相容性抗原Ⅱ类(Histocompatibility Antigens Class II);主要组织相容性复合物(Major Histocompatibility Complex);肿瘤(Neoplasms)

DOI 10.1021/acsnano.1c00897

PMID 33749234

发布时间 2021-05-14

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