Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes.

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第一作者： Cristina,Barca

第一单位： European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;PET Imaging in Drug Design and Development (PET3D).

作者： Cristina,Barca ^[1] ; Maximilian,Wiesmann ^[2] ; Jesús,Calahorra ^[3] ; Lydia,Wachsmuth ^[4] ; Christian,Döring ^[5] ; Claudia,Foray ^[1] ; Ali,Heiradi ^[6] ; Sven,Hermann ^[7] ; Maria Ángeles,Peinado ^[3] ; Eva,Siles ^[3] ; Cornelius,Faber ^[4] ; Michael,Schäfers ^[8] ; Amanda J,Kiliaan ^[2] ; Andreas H,Jacobs ^[9] ; Bastian,Zinnhardt ^[10]

作者单位： European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;PET Imaging in Drug Design and Development (PET3D). ^[1] Department of Medical Imaging, Anatomy, Radboud University Medical Center, Nijmegen, The Netherlands. ^[2] Department of Experimental Biology, University of Jaén, Campus las Lagunillas, Jaén, Spain. ^[3] Department of Radiology, Translational Research Imaging Center (TRIC), University Hospital Münster, Germany. ^[4] European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany. ^[5] Institute of Physiological Chemistry and Pathobiochemistry, University Hospital Münster, Germany. ^[6] European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;Immune Image, Innovative Medicines Initiative (IMI). ^[7] European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;Department of Nuclear Medicine, University Hospital Münster, Germany. ^[8] European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;PET Imaging in Drug Design and Development (PET3D).;Immune Image, Innovative Medicines Initiative (IMI).;Department of Geriatrics and Neurology, Johanniter Hospital, Bonn, Germany. ^[9] European Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.;PET Imaging in Drug Design and Development (PET3D).;Immune Image, Innovative Medicines Initiative (IMI).;Department of Nuclear Medicine, University Hospital Münster, Germany.;Biomarkers and Translational Technologies, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. ^[10]

关键词 Hydroxytyrosol TSPO [18]DPA-714 multimodal imaging neuroinflammation transient middle artery occlusion