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首页> Journal of molecular histology> Lyciumamide A, a dimer of phenolic amide, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.

Lyciumamide A, a dimer of phenolic amide, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.

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作者： Kai,Gao ^[1] ; Meiyou,Liu ^[1] ; Yuan,Li ^[2] ; Lei,Wang ^[1] ; Chao,Zhao ^[1] ; Xian,Zhao ^[1] ; Jinyi,Zhao ^[1] ; Yi,Ding ^[1] ; Haifeng,Tang ^[3] ; Yanyan,Jia ^[4] ; Jingwen,Wang ^[5] ; Aidong,Wen ^[6]

作者单位： Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. ^[1] Department of Pharmacy, Xi'an Children's Hospital, Xi'an, China. ^[2] Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an, China. ^[3] Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. 18691555435@163.com. ^[4] Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. wangjingwen8021@163.com. ^[5] Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. adwen-2004@hotmail.com. ^[6]

关键词 Lyciumamide A Molecular docking NMDA Neuroprotection Oxidative stress

主题词酰胺类(Amides);细胞凋亡(Apoptosis);钙(Calcium);钙-钙调素依赖性蛋白激酶2型(Calcium-Calmodulin-Dependent Protein Kinase Type 2);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);二聚作用(Dimerization);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);膜电位, 线粒体(Membrane Potential, Mitochondrial);N-甲基天冬氨酸(N-Methylaspartate);神经保护药(Neuroprotective Agents);神经毒素类(Neurotoxins);酚类(Phenols);磷酰化(Phosphorylation);活性氧(Reactive Oxygen Species);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1007/s10735-020-09952-y

PMID 33755822

发布时间 2021-11-25

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Journal of molecular histology

Journal of molecular histology

2021年52卷3期

449-459页

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