Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.

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第一作者： Firat,Kara

第一单位： Bio-imaging Lab- Member of INMIND consortium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: Kara.firat@mayo.edu.

作者： Firat,Kara ^[1] ; Michael E,Belloy ^[2] ; Rick,Voncken ^[2] ; Zahra,Sarwari ^[2] ; Yadav,Garima ^[2] ; Cynthia,Anckaerts ^[2] ; An,Langbeen ^[3] ; Valerie,Leysen ^[4] ; Disha,Shah ^[2] ; Jules,Jacobs ^[5] ; Julie,Hamaide ^[2] ; Peter,Bols ^[3] ; Johan,Van Audekerke ^[2] ; Jasmijn,Daans ^[6] ; Caroline,Guglielmetti ^[7] ; Kejal,Kantarci ^[8] ; Vincent,Prevot ^[4] ; Steffen,Roßner ^[9] ; Peter,Ponsaerts ^[6] ; Annemie,Van der Linden ^[2] ; Marleen,Verhoye ^[2]

作者单位： Bio-imaging Lab- Member of INMIND consortium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: Kara.firat@mayo.edu. ^[1] Bio-imaging Lab- Member of INMIND consortium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. ^[2] Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium. ^[3] Univ. Lille, Inserm, CHU Lille, Development and Plasticity of the Neuroendocrine Brain, Lille Neurosciences and Cognition, UMR-S1172, DistalZ, Lille, France. ^[4] University of Nijmegen, Nijmegen, the Netherlands. ^[5] Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium. ^[6] University of California San Francisco, San Francisco, California, USA. ^[7] Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. ^[8] Paul Flechsig Institute of Brain Research, Leipzig University, Leipzig, Germany. ^[9]

关键词 Alzheimer's disease Astrocytes Diffusion Tensor Imaging Tg2576 mice amyloid-beta (Aβ)functional connectivity human APP Swedish magnetic resonance spectroscopy ovarian hormones ovariectomy resting state fMRI