Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.

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第一作者： Peter A,Szabo

第一单位： Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

作者： Peter A,Szabo ^[1] ; Pranay,Dogra ^[1] ; Joshua I,Gray ^[1] ; Steven B,Wells ^[2] ; Thomas J,Connors ^[3] ; Stuart P,Weisberg ^[4] ; Izabela,Krupska ^[2] ; Rei,Matsumoto ^[5] ; Maya M L,Poon ^[6] ; Emma,Idzikowski ^[3] ; Sinead E,Morris ^[4] ; Chloé,Pasin ^[4] ; Andrew J,Yates ^[4] ; Amy,Ku ^[4] ; Michael,Chait ^[4] ; Julia,Davis-Porada ^[7] ; Xinzheng V,Guo ^[8] ; Jing,Zhou ^[9] ; Matthew,Steinle ^[9] ; Sean,Mackay ^[9] ; Anjali,Saqi ^[4] ; Matthew R,Baldwin ^[10] ; Peter A,Sims ^[11] ; Donna L,Farber ^[12]

作者单位： Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[1] Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[2] Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[3] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[4] Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[5] Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Medical Scientist Training Program, Columbia University, New York, NY 10032, USA. ^[6] Medical Scientist Training Program, Columbia University, New York, NY 10032, USA. ^[7] Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[8] IsoPlexis Corporation, Branford, CT 06405, USA. ^[9] Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[10] Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. ^[11] Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu. ^[12]

关键词 ARDS COVID-19 chemokines coronavirus disease 2019 cytokines lung immunity macrophages monocytes single-cell RNA sequencing tissue resident memory T?cells